This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants.
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13; A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 13; Von Willebrand Factor-Cleaving Protease; VWF-Cleaving Protease; ADAM-TS13; ADAMTS-13; C9orf8; VWF-CP;