KLH conjugated phosphopeptide, mouse AANAT around Thr29
Human, Mouse, Rat
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.
Aralkylamine N-Acetyltransferase; Arylalkylamine N-Acetyltransferase; Serotonin N-Acetyltransferase; Serotonin Acetylase; EC 220.127.116.11; SNAT; AA-NAT; DSPS;