This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Adiponectin, C1Q And Collagen Domain Containing; Adipose Most Abundant Gene Transcript 1 Protein; Adipocyte Complement-Related 30 KDa Protein; 30 KDa Adipocyte Complement-Related Protein; ACRP30; APM-1; GBP28; ACDC; APM1; Adipocyte, C1q And Collagen Domain-Containing Protein; Adipocyte, C1Q And Collagen Domain Containing; Adipose Most Abundant Gene Transcript 1; Adipose Specific Collagen-Like Factor; Gelatin-Binding Protein 28; Gelatin-Binding Protein; Adiponectin Precursor; ADIPQTL1; ADPN