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Mouse Anti-AGER Recombinant Antibody (BA0395) (CBMAB-0040CQ)

This product is a mouse antibody that recognizes AGER. The antibody BA0395 can be used for immunoassay techniques such as: FC, IHC-P, WB.
Host Species
Mouse
Application
FC, IHC-P, WB
Immunogen
Human RAGE amino acids 23-405
Antibody Isotype
IgG2a
Specificity
Human, Rat
Clone
BA0395
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
RAGE, a multiligand member of the immunoglobulin superfamily of cell surface molecules, interacts with distinct molecules implicated in homeostasis, development, and inflammation, and certain diseases such as diabetes and Alzheimer disease. The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene.
Alternative Name
Advanced Glycosylation End Product-Specific Receptor; RAGE; Receptor For Advanced Glycation End-Products Variant 20; Receptor For Advanced Glycosylation End Products; RAGE Isoform NtRAGE-Delta; RAGE Isoform SRAGE-Delta
Entrez Gene ID
Human177
Rat81722
UniProt ID
HumanQ15109
RatQ63495
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-0040CQ
Conjugates
Size
Price $
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Second antibody and isotype control