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Mouse Anti-AIMP1 Recombinant Antibody (V2-12548) (CBMAB-1038-CN)

This product is a mouse antibody that recognizes AIMP1 of human. The antibody 3H5 can be used for immunoassay techniques such as: ELISA, WB.
See all AIMP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-12548
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
SCYE1 (AAH14051, aa. 1-312) full-length recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Localized in aa. 1-312

Target

Full Name
Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 1
Introduction
The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This is a non-catalytic component of the multisynthase complex. It stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase.
Entrez Gene ID
9255
UniProt ID
Q12904
Alternative Names
p43; HLD3; EMAP2; SCYE1; EMAPII
Function
Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550).
Biological Process
Angiogenesis Source: UniProtKB-KW
Apoptotic process Source: UniProtKB-KW
Cell-cell signaling Source: HGNC-UCL
Defense response to virus Source: Ensembl
Inflammatory response Source: UniProtKB-KW
Leukocyte migration Source: HGNC-UCL
Negative regulation of endothelial cell proliferation Source: HGNC-UCL
Positive regulation of glucagon secretion Source: UniProtKB
tRNA aminoacylation for protein translation Source: Reactome
Cellular Location
Golgi apparatus; Secreted; Nucleus; Endoplasmic reticulum; Cytosol. Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Secreted in response to hypoxia (PubMed:10850427). Also secreted in response to both apoptotic and necrotic cell death.
Involvement in disease
Leukodystrophy, hypomyelinating, 3 (HLD3): A severe autosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmental delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous system.
PTM
Cleaved by caspase-7 in response to apoptosis to produce EMAP-II.

Lee, D. D., Hochstetler, A., Sah, E., Xu, H., Lowe, C. W., Santiaguel, S., ... & Schwarz, M. A. (2020). Influence of aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1 on epithelial differentiation and organization during lung development. American Journal of Physiology-Lung Cellular and Molecular Physiology, 319(2), L369-L379.

Mun, C. H., Kim, J. O., Ahn, S. S., Yoon, T., Kim, S. J., Ko, E., ... & Park, S. G. (2019). Atializumab, a humanized anti-aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) antibody significantly improves nephritis in (NZB/NZW) F1 mice. Biomaterials, 220, 119408.

Ahn, S. S., Kim, J. O., Yoon, T., Song, J. J., Park, Y. B., Lee, S. W., & Park, S. G. (2019). Serum aminoacyl-tRNA synthetase-interacting multifunctional protein-1 can predict severe antineutrophil cytoplasmic antibody-associated vasculitis: a pilot monocentric study. BioMed research international, 2019.

Accogli, A., Russell, L., Sébire, G., Rivière, J. B., St-Onge, J., Addour-Boudrahem, N., ... & Srour, M. (2019). Pathogenic variants in AIMP1 cause pontocerebellar hypoplasia. neurogenetics, 20(2), 103-108.

Khan, A., Bennett, J., Scantlebury, M. H., Wei, X. C., & Kerr, M. (2019). AIMP1 mutation long-term follow-up, with decreased brain N-acetylaspartic acid and secondary mitochondrial abnormalities. Child neurology open, 6, 2329048X19829520.

Kim, M. S., Song, J. H., Cohen, E. P., Cho, D., & Kim, T. S. (2017). Aminoacyl tRNA synthetase–interacting multifunctional protein 1 activates NK cells via macrophages in vitro and in vivo. The Journal of Immunology, 198(10), 4140-4147.

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For research use only. Not intended for any clinical use.

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