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Mouse Anti-AKIP1 Recombinant Antibody (V2-180444) (CBMAB-A1952-YC)

Provided herein is a Mouse monoclonal antibody against Human A-Kinase Interacting Protein 1. The antibody can be used for immunoassay techniques, such as IHC.
See all AKIP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180444
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Full length human recombinant protein of human AKIP1 (NP_878904) produced in E. coli
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
A-Kinase Interacting Protein 1
Introduction
AKIP1 is a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
Entrez Gene ID
56672
UniProt ID
Q9NQ31
Alternative Names
A-Kinase Interacting Protein 1; A Kinase (PRKA) Interacting Protein 1; Proline-Rich Protein BCA3; C11orf17; BCA3; Breast Cancer-Associated Gene 3 Protein; Chromosome 11 Open Reading Frame 17;
Function
Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
Biological Process
Regulation of NIK/NF-kappaB signaling Source: InterPro
Substrate adhesion-dependent cell spreading Source: Ensembl
Cellular Location
Nucleus. Locates to punctate spots.

Sun, Y., Shi, G., Ma, C., Jiao, J., Liu, Y., Gao, Q., ... & Feng, Q. (2021). Upregulation of a kinase interacting protein 1 in tongue squamous cell carcinoma correlates with lymph node metastasis and poor overall survival. Medicine, 100(14).

Zhang, X., Liu, S., & Zhu, Y. (2020). A‐kinase‐interacting protein 1 promotes EMT and metastasis via PI3K/Akt/IKKβ pathway in cervical cancer. Cell biochemistry and function, 38(6), 782-791.

Hao, X., Gu, M., Sun, J., & Cong, L. (2020). A‐kinase interacting protein 1 might serve as a novel biomarker for worse prognosis through the interaction of chemokine (C‐X‐C motif) ligand 1/chemokine (C‐X‐C motif) ligand 2 in acute myeloid leukemia. Journal of clinical laboratory analysis, 34(2), e23052.

Chen, H., Yan, S., Dong, L., & Li, X. (2020). A‐kinase‐interacting protein 1 overexpression correlates with deteriorative tumor features and worse survival profiles, and promotes cell proliferation but represses apoptosis in non‐small‐cell lung cancer. Journal of clinical laboratory analysis, 34(2), e23061.

Wang, D., Luo, Y., Guo, Y., Li, G., & Li, F. (2020). A-kinase interacting protein 1, a potential biomarker associated with advanced tumor features and CXCL1/2 in prostate cancer. The International journal of biological markers, 35(2), 74-81.

Fang, T., & Lu, Q. (2020). A‐kinase interacting protein 1 (AKIP1) associates with advanced overall disease condition, tumor properties, and unfavorable prognosis in hepatocellular carcinoma patients. Journal of clinical laboratory analysis, 34(6), e23213.

Yan, Y., Li, X., & Gao, J. (2020). Identification of A‐kinase interacting protein 1 as a potential biomarker for risk and prognosis of acute myeloid leukemia. Journal of clinical laboratory analysis, 34(5), e23055.

Zhang, L., Tao, H., Ke, K., & Ma, C. (2020). A‐kinase interacting protein 1 as a potential biomarker of advanced tumor features and increased recurrence risk in papillary thyroid carcinoma patients. Journal of clinical laboratory analysis, 34(10), e23452.

Chen, D., Cao, G., & Liu, Q. (2019). A‐kinase‐interacting protein 1 facilitates growth and metastasis of gastric cancer cells via Slug‐induced epithelial‐mesenchymal transition. Journal of cellular and molecular medicine, 23(6), 4434-4442.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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