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Mouse Anti-AKT1 Recombinant Antibody (CBYY-0010) (CBMAB-0010-YY)

This product is mouse antibody that recognizes AKT1. The antibody CBYY-0010 can be used for immunoassay techniques such as: ELISA, IHC, WB
Host Species
Mouse
Application
ELISA, IHC, WB
Antibody Isotype
IgG1
Specificity
Human, Mouse
Clone
CBYY-0010
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Alternative Name
AKT Serine/Threonine Kinase 1; V-Akt Murine Thymoma Viral Oncogene Homolog 1; Protein Kinase B Alpha; Proto-Oncogene C-Akt; RAC-PK-Alpha; EC 2.7.11.1; PKB Alpha; PKB; RAC; V-Akt Murine Thymoma Viral Oncogene-Like Protein 1; RAC-Alpha Serine/Threonine-Protein Kinase;
Entrez Gene ID
Human207
Mouse11651
UniProt ID
HumanP31749
MouseP31750
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-0010-YY
Conjugates
Size
Price $
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Second antibody and isotype control