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Rabbit Anti-ALDH3A2 Recombinant Antibody (EPR15425(B)) (CBMAB-1062-CN)

This product is a rabbit antibody that recognizes ALDH3A2 of human. The antibody EPR15425(B) can be used for immunoassay techniques such as: FC, IF, WB.
See all ALDH3A2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EPR15425(B)
Antibody Isotype
IgG
Application
FC, IF, WB

Basic Information

Immunogen
Synthetic peptide within Human Aldehyde dehydrogenase 10 (aa. 300-400).
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000-1:10,000
IF(ICC)1:250
FC1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
59% PBS, 40% Glycerol, 0.05% BSA
Preservative
0.01% Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Aldehyde Dehydrogenase 3 Family Member A2
Introduction
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This protein catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. It actives on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. It's also responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
Entrez Gene ID
Human224
Mouse11671
UniProt ID
HumanP51648
MouseP47740
Alternative Names
SLS; FALDH; ALDH10
Function
Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030, PubMed:18035827, PubMed:9662422, PubMed:18182499). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490).
Biological Process
Cellular aldehyde metabolic process Source: UniProtKB
Central nervous system development Source: UniProtKB
Epidermis development Source: UniProtKB
Fatty acid alpha-oxidation Source: Reactome
Hexadecanal metabolic process Source: UniProtKB
Peripheral nervous system development Source: UniProtKB
Phytol metabolic process Source: UniProtKB
Protein import into peroxisome membrane Source: Reactome
Protein insertion into ER membrane Source: Reactome
Sesquiterpenoid metabolic process Source: UniProtKB
Sphingolipid biosynthetic process Source: Reactome
Cellular Location
Microsome membrane; Endoplasmic reticulum membrane
Involvement in disease
Sjoegren-Larsson syndrome (SLS): An autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis. Ichthyosis is usually evident at birth with varying degrees of erythema and scaling, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects.
Topology
Cytoplasmic: 1-463 aa
Helical: 464-484 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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