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Rabbit Anti-ANPEP Recombinant Antibody (122) (CBMAB-C2577-LY)

This product is antibody recognizes ANPEP. The antibody 122 immunoassay techniques such as: ELISA, WB, IHC-P.
See all ANPEP antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
122
Antibody Isotype
IgG
Application
ELISA, WB, IHC-P

Basic Information

Immunogen
Recombinant Human CD13/ANPEP protein. This antibody was obtained from a rabbit immunized with purified, recombinant Human CD13/ANPEP
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:5,000-1:10,000
WB1:500-1:2,000
IHC-P1:100-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Alanyl Aminopeptidase, Membrane
Introduction
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
Entrez Gene ID
290
UniProt ID
P15144
Alternative Names
Alanyl Aminopeptidase, Membrane; Microsomal Aminopeptidase; Aminopeptidase M; Myeloid Plasma Membrane Glycoprotein CD13; Alanyl (Membrane) Aminopeptidase; Membrane Alanyl Aminopeptidase; Aminopeptidase N; EC 3.4.11.2; GP150; CD13; PEPN;
Function
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).
(Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein.
(Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.
Biological Process
Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Neutrophil degranulation Source: Reactome
Peptide catabolic process Source: GO_Central
Proteolysis Source: GO_Central
Regulation of blood pressure Source: GO_Central
Signal transduction Source: GO_Central
Cellular Location
Cell membrane. Also found as a soluble form.
Topology
Cytoplasmic: 2-8 aa
Helical: 9-32 aa
Extracellular: 33-967 aa
PTM
Sulfated.
N- and O-glycosylated.
May undergo proteolysis and give rise to a soluble form.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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