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Rabbit Anti-APOE Recombinant Antibody (16H22L18) (CBMAB-0075CQ)

This product is a rabbit antibody that recognizes APOE. The antibody 16H22L18 can be used for immunoassay techniques such as: WB, IF, ICC.
Host Species
Rabbit
Application
WB, IF, ICC
Immunogen
Peptide between 240–251 of human ApoE
Antibody Isotype
IgG
Specificity
Human, Mouse, Rat
Clone
16H22L18
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
Apolipoprotein E is the recognition site for receptors involved in the clearance of remnants of very low density lipoproteins and chylomicrons. The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. ApoE, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. The E2 variant binds less readily. Weisgraber et al. showed that human E apoprotein of the E2 form, which contains cysteine (rather than arginine) at both of the 2 variable sites, binds poorly with cell surface receptors, whereas E3 and E4 bind well.
Alternative Name
Apolipoprotein E; APO-E; Alzheimer Disease 2 (APOE*E4-Associated, Late Onset); Apolipoprotein E3; LDLCQ5; LPG; AD2
Entrez Gene ID
Human348
Mouse11816
Rat25728
UniProt ID
HumanP02649
MouseP08226
RatP02650
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-0075CQ
Conjugates
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Second antibody and isotype control