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Mouse Anti-B2M Recombinant Antibody (CBYY-0043) (CBMAB-0043-YY)

This product is mouse antibody that recognizes B2M. The antibody CBYY-0043 can be used for immunoassay techniques such as: ELISA, WB, IHC, FC
Host Species
Mouse
Application
ELISA, WB, IHC, FC
Immunogen
B2M monoclonal antibody was raised against pufified B2M (Human)
Antibody Isotype
IgG1
Cross Reactivity
Human
Clone
CBYY-0043
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercataBovinelic hypoproteinemia.
B2M (Beta-2-Microglobulin) is a Protein Coding gene.
Diseases associated with B2M include Immunodeficiency 43 and Amyloidosis, Familial Visceral.
Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System.
Gene Ontology (GO) annotations related to this gene include identical protein binding.
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Alternative Name
Beta-2-Microglobulin; Beta Chain Of MHC Class I Molecules; Beta-2-Microglobin; IMD43;
Entrez Gene ID
UniProt ID
Cat CBMAB-0043-YY
Conjugates
Size
Price $
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