Detects endogenous levels of total Bad only when phosphorylated at Ser112. Does not detect Bad phosphorylated at other sites. Nor does it detect related family members. Species Crossreactivity: Human, mouse, monkey and rat. Other species have not been tested
Human, Monkey, Mouse, Rat
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
BCL2 Associated Agonist Of Cell Death; Bcl-XL/Bcl-2-Associated Death Promoter; Bcl2 Antagonist Of Cell Death; Bcl-2-Binding Component 6; Bcl-2-Like Protein 8; Bcl2-L-8; BCL2L8; BCL2-Antagonist Of Cell Death Protein;