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Rabbit Anti-BPIFA1 Recombinant Antibody (CBYC-P029) (CBMAB-P0113-YC)

Provided herein is a Rabbit monoclonal antibody against Human BPI Fold Containing Family A Member 1. The antibody can be used for immunoassay techniques, such as WB, IP, FC.
See all BPIFA1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBYC-P029
Antibody Isotype
IgG
Application
WB, IP, FC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Bpi Fold Containing Family A Member 1
Introduction
BPIFA1 is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known.
Entrez Gene ID
Human51297
Mouse18843
Rat246238
UniProt ID
HumanQ9NP55
MouseP97361
RatQ8K4I4
Alternative Names
BPI Fold Containing Family A Member 1; Palate Lung And Nasal Epithelium Clone Protein; Secretory Protein In Upper Respiratory Tracts; Palate, Lung And Nasal Epithelium Associated; Nasopharyngeal Carcinoma-Related Protein; Lung-Specific Protein X; Von Ebner Protein Hl; Short PLUNC1; SPLUNC1; PLUNC; SPURT;
Function
Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed:25223608).
Plays a role in the innate immune responses of the upper airways (PubMed:23499554, PubMed:23132494).
Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23499554, PubMed:23132494, PubMed:27145151).
Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed:24124190, PubMed:24043776).
Plays a role in the airway inflammatory response after exposure to irritants (PubMed:11425234).
May attract macrophages and neutrophils (PubMed:23132494).
Biological Process
Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Defense response to virus Source: UniProtKB
Immune response in nasopharyngeal-associated lymphoid tissue Source: UniProtKB
Innate immune response Source: UniProtKB
Multicellular organismal water homeostasis Source: UniProtKB
Negative regulation of single-species biofilm formation in or on host organism Source: UniProtKB
Regulation of liquid surface tension Source: UniProtKB
Regulation of sodium ion transmembrane transport Source: UniProtKB
Cellular Location
Secreted. Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
PTM
May be N-glycosylated.

Zhang, R., Trower, J., & Wu, T. (2020). Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease Der p 1 abrogates immune modulator function. International journal of biological macromolecules, 164, 4022-4031.

Saferali, A., Tang, A. C., Strug, L. J., Quon, B. S., Zlosnik, J., Sandford, A. J., & Turvey, S. E. (2020). Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1. Plos one, 15(1), e0227067.

Britto, C. J., Niu, N., Khanal, S., Huleihel, L., Herazo-Maya, J. D., Thompson, A., ... & Cohn, L. E. (2019). BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation. American journal of physiology-lung cellular and molecular physiology, 316(2), L321-L333.

Khanal, S., Niu, N., Sharma, L., Liu, W., Cohn, L., Cruz, C. D., & Britto, C. (2019). BPI-fold containing Family A member 1 (Bpifa1) Role in IFN Driven Pulmonary Response.

Khanal, S., Niu, N., Huleihel, L., Herazo-Maya, J., Kaminski, N., Cohn, L., & Britto, C. (2018). BPI Fold-Containing Family A Member 1 (BPIFA1) regulates lung neutrophil recruitment and interferon signaling during acute inflammation.

Britto, C., Khanal, S., Wu, B., Li, Y., & Segal, L. (2018). BPI Fold Containing Family A Member 1 (BPIFA1) regulates mucosal microbiota and basal Interferon signaling.

Britto-Leon, C. J., Khanal, S., Wu, B., Li, Y., & Segal, L. N. (2018). BPI-Fold Containing Family A Member 1 (BPIFA1) Regulates Mucosal Immunity and Airway Microbiota. In D107. HOST PATHOGEN INTERACTIONS (pp. A7568-A7568). American Thoracic Society.

Wang, H., Jiang, D., Li, W., & Wang, S. (2017). Increased expression of BPI fold‑containing family A member 1 is associated with metastasis and poor prognosis in human colorectal carcinoma. Oncology letters, 14(4), 4231-4236.

Guo, Y., Guo, L. N., Zhu, J. F., Tang, C. Y., Feng, Y. Z., & Zhou, H. D. (2017). Associations of salivary BPIFA1 protein in chronic periodontitis patients with type 2 diabetes mellitus. International journal of endocrinology, 2017.

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For research use only. Not intended for any clinical use.

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