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Mouse Anti-BTG2 (AA 1-146) Recombinant Antibody (CBYY-0871) (CBMAB-0874-YY)

This product is mouse antibody that recognizes BTG2. The antibody CBYY-0871 can be used for immunoassay techniques such as: WB
See all BTG2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0871
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human BTG2(NP_006754) produced in E.coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1.00mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-146

Target

Full Name
BTG family, member 2
Introduction
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle.
Entrez Gene ID
UniProt ID
Alternative Names
BTG Anti-Proliferation Factor 2; NGF-Inducible Anti-Proliferative Protein PC3; BTG Family Member 2; Nerve Growth Factor-Inducible Anti-Proliferative; B-Cell Translocation Gene 2; Pheochromacytoma Cell-3;
Function
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity).
Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.
Biological Process
Anterior/posterior pattern specification Source: Ensembl
Associative learning Source: Ensembl
Cellular response to DNA damage stimulus Source: MGI
Central nervous system neuron development Source: Ensembl
Dentate gyrus development Source: Ensembl
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
DNA repair Source: ProtInc
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of mitotic cell cycle Source: GO_Central
Negative regulation of neural precursor cell proliferation Source: Ensembl
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Negative regulation of translation Source: UniProtKB
Neuron projection development Source: UniProtKB
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: MGI
Protein methylation Source: Ensembl
Response to electrical stimulus Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Response to peptide hormone Source: Ensembl
Skeletal muscle cell differentiation Source: Ensembl
Cellular Location
Cytosol; Extracellular exosome; Nucleus; Cytoplasm
PTM
Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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