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Mouse Anti-C5AR2 Recombinant Antibody (CBFYC-0095) (CBMAB-C0112-FY)

This product is mouse antibody that recognizes C5AR2. The antibody CBFYC-0095 can be used for immunoassay techniques such as: FC.
See all C5AR2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-0095
Antibody Isotype
IgG2a, k
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
complement component 5a receptor 2
Introduction
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response.
Entrez Gene ID
27202
UniProt ID
Q9P296
Alternative Names
C5L2; GPF77; GPR77
Function
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.
Biological Process
Chemotaxis Source: InterPro
Complement receptor mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Negative regulation of interleukin-6 production Source: UniProtKB
Negative regulation of neutrophil chemotaxis Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of epithelial cell proliferation Source: InterPro
Positive regulation of ERK1 and ERK2 cascade Source: InterPro
Regulation of complement activation Source: Reactome
Regulation of interleukin-8 production Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 1-38 aa
Helical: 39-61 aa
Cytoplasmic: 62-72 aa
Helical: 73-95 aa
Extracellular: 96-114 aa
Helical: 115-137 aa
Cytoplasmic: 138-149 aa
Helical: 150-172 aa
Extracellular: 173-202 aa
Helical: 203-225 aa
Cytoplasmic: 226-237 aa
Helical: 238-260 aa
Extracellular: 261-274 aa
Helical: 275-294 aa
Cytoplasmic: 295-337 aa

Wu, M. C., Lee, J. D., Ruitenberg, M. J., & Woodruff, T. M. (2020). Absence of the C5a Receptor C5aR2 Worsens Ischemic Tissue Injury by Increasing C5aR1-Mediated Neutrophil Infiltration. The Journal of Immunology, 205(10), 2834-2839.

Miyabe, Y., Miyabe, C., Mani, V., Mempel, T. R., & Luster, A. D. (2019). Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation. Science immunology, 4(35).

Li, X. X., Lee, J. D., Kemper, C., & Woodruff, T. M. (2019). The complement receptor C5aR2: a powerful modulator of innate and adaptive immunity. The Journal of Immunology, 202(12), 3339-3348.

Nabizadeh, J. A., Manthey, H. D., Panagides, N., Steyn, F. J., Lee, J. D., Li, X. X., ... & Rolfe, B. E. (2019). C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma. The FASEB Journal, 33(10), 11060-11071.

Verghese, D. A., Demir, M., Chun, N., Fribourg, M., Cravedi, P., Llaudo, I., ... & Heeger, P. S. (2018). T cell expression of C5a receptor 2 augments murine regulatory T cell (TREG) generation and TREG-dependent cardiac allograft survival. The Journal of Immunology, 200(6), 2186-2198.

Orrem, H. L., Nilsson, P. H., Pischke, S. E., Kleveland, O., Yndestad, A., Ekholt, K., ... & Mollnes, T. E. (2018). IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction. Frontiers in immunology, 9, 2035.

Zhang, T., Garstka, M. A., & Li, K. (2017). The controversial C5a receptor C5aR2: its role in health and disease. Journal of immunology research, 2017.

Kovtun, A., Bergdolt, S., Hägele, Y., Matthes, R., Lambris, J. D., Huber-Lang, M., & Ignatius, A. (2017). Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair. Scientific reports, 7(1), 1-12.

Poppelaars, F., van Werkhoven, M. B., Kotimaa, J., Veldhuis, Z. J., Ausema, A., Broeren, S. G., ... & Seelen, M. A. (2017). Critical role for complement receptor C5aR2 in the pathogenesis of renal ischemia‐reperfusion injury. The FASEB Journal, 31(7), 3193-3204.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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