Mouse Anti-C8a Recombinant Antibody (CBXC-0028) (CBMAB-C5948-CQ)

This product is a mouse antibody that recognizes C8a. The antibody CBXC-0028 can be used for immunoassay techniques such as: ELISA, FC, IHC, WB.
See all C8a antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXC-0028

Antibody Isotype

IgG1

Application

ELISA, FC, IHC, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

complement C8 alpha chain

Entrez Gene ID

731

UniProt ID

P07357

Alternative Names

complement C8 alpha chain

Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.

Biological Process

Complement activation Source: MGI
Complement activation, alternative pathway Source: UniProtKB-KW
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Immune response Source: ProtInc
Regulation of complement activation Source: Reactome

Cellular Location

Cell membrane; Secreted. Secreted as soluble protein. Inserts into the cell membrane of target cells.

Involvement in disease

Complement component 8 deficiency, 1 (C8D1): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

References

Li, L., Yang, W., Shen, Y., Xu, X., & Li, J. (2020). Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59. Mol Immunol, 235-248.

Densen, P., Ackermann, L., Saucedo, L., Figueroa, J. E., Si, Z. H., & Stoltzfus, C. M. (2020). A Point Mutation Creating a 3′ Splice Site in C8A Is a Predominant Cause of C8α-γ Deficiency in African Americans. The Journal of Immunology, 205(6), 1535-1539.

Willis, S., Polydoropoulou, V., Sun, Y., Young, B., Tsourti, Z., Karlis, D., ... & Leyland-Jones, B. (2018). Exploratory analysis of single-gene predictive biomarkers in HERA DASL cohort reveals that C8A mRNA expression is prognostic of outcome and predictive of benefit of trastuzumab. JCO Precision Oncology, 2, 1-12.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-C8A Recombinant Antibody (056B-373)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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