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Mouse Anti-C8B Recombinant Antibody (056B-373) (CBMAB-C1202-CN)

This product is a Mouse antibody that recognizes C8B. The antibody 056B-373 can be used for immunoassay techniques such as: IHC, ELISA, WB, FC.
See all C8B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
056B-373
Antibody Isotype
IgG1
Application
IHC, ELISA, WB, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Complement C8 beta chain
Introduction
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
UniProt ID
Alternative Names
C82
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Biological Process
Complement activation Source: Reactome
Complement activation, alternative pathway Source: UniProtKB-KW
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Immune response Source: ProtInc
Regulation of complement activation Source: Reactome
Cellular Location
Secreted
Involvement in disease
Complement component 8 deficiency, 2 (C8D2): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
PTM
N-glycosylated; contains one or two bound glycans. Not O-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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