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Rat Anti-CA12 Recombinant Antibody (CBYY-C0828) (CBMAB-C2264-YY)

This product is rat antibody that recognizes CA12. The antibody CBYY-C0828 can be used for immunoassay techniques such as: WB
See all CA12 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-C0828
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Carbonic Anhydrase XII/CA12, Ala25-Ser301, Accession # Q8CI85
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A/G purified
Buffer
LYOPH
Preservative
PBS
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Carbonic Anhydrase 12
Entrez Gene ID
76459
UniProt ID
Q8CI85
Alternative Names
Calcium Voltage-Gated Channel Subunit Alpha1 A; Calcium Channel, Voltage-Dependent, P/Q Type, Alpha 1A Subunit; Voltage-Gated Calcium Channel Subunit Alpha Cav2.1; Brain Calcium Channel I; CACNL1A4; BI; Fetal Brain Ca2+ Voltage-Gated Channel Alpha1A Pore-Forming Subunit; Voltage-Dependent P/Q-Type Calcium Channel Subunit Alpha-1A; Calcium Channel, L Type, Alpha-1 Polypeptide Isoform 4; Calcium Channel, L Type, Alpha-1 Polypeptide; Brain Calcium Channel 1; CAV2.1;
Function
Reversible hydration of carbon dioxide.
Biological Process
Bicarbonate transport Source: Reactome
Chloride ion homeostasis Source: UniProtKB
One-carbon metabolic process Source: GO_Central
Cellular Location
Cell membrane; Membrane
Involvement in disease
Hyperchlorhidrosis, isolated (HYCHL): An autosomal recessive disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.
Topology
Extracellular: 25-301 aa
Helical: 302-322 aa
Cytoplasmic: 323-354 aa

Li, G., Chen, T. W., Nickel, A. C., Muhammad, S., Steiger, H. J., Tzaridis, T., ... & Kahlert, U. D. (2021). Carbonic Anhydrase XII is a Clinically Significant, Molecular Tumor-Subtype Specific Therapeutic Target in Glioma with the Potential to Combat Invasion of Brain Tumor Cells. OncoTargets and therapy, 14, 1707.

Zhao, X., Shen, P., Li, H., Yang, Y., Guo, J., Chen, S., ... & Fang, X. (2020). Carbonic Anhydrase 12 Protects Endplate Cartilage From Degeneration Regulated by IGF-1/PI3K/CREB Signaling Pathway. Frontiers in cell and developmental biology, 8, 1123.

Franke, C. M., Gu, V. W., Grimm, B. G., Cassady, V. C., White, J. R., Weigel, R. J., & Kulak, M. V. (2020). TFAP2C regulates carbonic anhydrase XII in human breast cancer. Oncogene, 39(6), 1290-1301.

Hwang, S., Kang, J. Y., Kim, M. J., Shin, D. M., & Hong, J. H. (2019). Carbonic anhydrase 12 mutation modulates membrane stability and volume regulation of aquaporin 5. Journal of enzyme inhibition and medicinal chemistry, 34(1), 179-188.

Li, Y., Lei, B., Zou, J., Wang, W., Chen, A., Zhang, J., ... & Li, Z. (2019). High expression of carbonic anhydrase 12 (CA12) is associated with good prognosis in breast cancer. Neoplasma, 66(3), 420-426.

Uda, N. R., Stenner, F., Seibert, V., Herzig, P., Markuly, N., Van Dijk, M., ... & Renner, C. (2019). Humanized monoclonal antibody blocking carbonic anhydrase 12 enzymatic activity leads to reduced tumor growth in vitro. Anticancer research, 39(8), 4117-4128.

Hwang, S., Shin, D. M., & Hong, J. H. (2019). Drug Repurposing as an Antitumor Agent: Disulfiram-Mediated Carbonic Anhydrase 12 and Anion Exchanger 2 Modulation to Inhibit Cancer Cell Migration. Molecules, 24(18), 3409.

Avital, D., Hershkovitz, E., & Loewenthal, N. (2018). Exertional rhabdomyolysis in carbonic anhydrase 12 deficiency. Journal of Pediatric Endocrinology and Metabolism, 31(6), 697-699.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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