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Rat Anti-CA2 Recombinant Antibody (CBYY-C0846) (CBMAB-C2282-YY)

This product is rat antibody that recognizes CA2. The antibody CBYY-C0846 can be used for immunoassay techniques such as: ELISA, WB
See all CA2 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
CBYY-C0846
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa2-260 of human CA2 expressed in E. coli (P00918, NP_000058)
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Buffer
0.5 mg/mL
Preservative
PBS, 5% trehalose
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Carbonic anhydrase 2
Entrez Gene ID
760
UniProt ID
P00918
Alternative Names
Calbindin 2; 29 KDa Calbindin; Calretinin; CAB29; CR; Testicular Secretory Protein Li 8;
Function
Essential for bone resorption and osteoclast differentiation (By similarity).
Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.
Biological Process
Angiotensin-activated signaling pathway Source: UniProtKB
Bicarbonate transport Source: Reactome
Carbon dioxide transport Source: GO_Central
Cellular response to fluid shear stress Source: Ensembl
Kidney development Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
One-carbon metabolic process Source: GO_Central
Positive regulation of bone resorption Source: Ensembl
Positive regulation of cellular pH reduction Source: Ensembl
Positive regulation of dipeptide transmembrane transport Source: UniProtKB
Positive regulation of osteoclast differentiation Source: Ensembl
Regulation of anion transport Source: UniProtKB
Regulation of intracellular pH Source: UniProtKB
Response to estrogen Source: Ensembl
Response to pH Source: Ensembl
Response to steroid hormone Source: Ensembl
Response to zinc ion Source: Ensembl
Cellular Location
Cytoplasm; Cell membrane. Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.
Involvement in disease
Osteopetrosis, autosomal recessive 3 (OPTB3): A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.

Kennedy, C. R., Goya Grocin, A., Kovačič, T., Singh, R., Ward, J. A., Shenoy, A. R., & Tate, E. W. (2021). A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target. ACS Chemical Biology.

Li, C., Qin, L., Huang, J., Zhan, Y., Yu, G., Huang, H., & Huang, D. (2021). Carbonic anhydrase 2 is a promising predictive factor in cholangiocarcinoma and potential mediator in Metformin treatment.

Shaik, N. A., Bokhari, H. A., Masoodi, T. A., Shetty, P. J., Ajabnoor, G. M., Elango, R., & Banaganapalli, B. (2020). Molecular modelling and dynamics of CA2 missense mutations causative to carbonic anhydrase 2 deficiency syndrome. Journal of Biomolecular Structure and Dynamics, 38(14), 4067-4080.

Hannen, R., Selmansberger, M., Hauswald, M., Pagenstecher, A., Nist, A., Stiewe, T., ... & Bartsch, J. W. (2019). Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase CA2 Gene as Resistance Factor. Cancers, 11(7), 921.

Feng, S., Wang, S., Wang, Y., Yang, Q., Wang, D., & Li, H. (2018). Identification and expression of carbonic anhydrase 2, myosin regulatory light chain 2 and selenium-binding protein 1 in zebrafish Danio rerio: Implication for age-related biomarkers. Gene Expression Patterns, 29, 47-58.

Zhang, C., Wang, H., Chen, Z., Zhuang, L., Xu, L., Ning, Z., ... & Meng, Z. (2018). Carbonic anhydrase 2 inhibits epithelial–mesenchymal transition and metastasis in hepatocellular carcinoma. Carcinogenesis, 39(4), 562-570.

Ip, Y. K., Koh, C. Z., Hiong, K. C., Choo, C. Y., Boo, M. V., Wong, W. P., ... & Chew, S. F. (2017). Carbonic anhydrase 2‐like in the giant clam, Tridacna squamosa: characterization, localization, response to light, and possible role in the transport of inorganic carbon from the host to its symbionts. Physiological reports, 5(23), e13494.

Tachibana, H., Gi, M., Kato, M., Yamano, S., Fujioka, M., Kakehashi, A., ... & Wanibuchi, H. (2017). Carbonic anhydrase 2 is a novel invasion‐associated factor in urinary bladder cancers. Cancer science, 108(3), 331-337.

Barinda, A. J., Ikeda, K., Hirata, K. I., & Emoto, N. (2017). Macrophages highly express carbonic anhydrase 2 and play a significant role in demineralization of the ectopic calcification. Kobe Journal of Medical Sciences, 63(2), E45.

Luo, Y., Mok, T. S., Lin, X., Zhang, W., Cui, Y., Guo, J., ... & Wang, T. (2017). SWATH-based proteomics identified carbonic anhydrase 2 as a potential diagnosis biomarker for nasopharyngeal carcinoma. Scientific reports, 7(1), 1-11.

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For research use only. Not intended for any clinical use.

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