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Rabbit Anti-CABIN1 Recombinant Antibody (13G22) (CBMAB-C1225-CN)

This product is a Rabbit antibody that recognizes CABIN1. The antibody 13G22 can be used for immunoassay techniques such as: IP, WB.
See all CABIN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
13G22
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues near the C-terminal domain of human CABIN1. Species Sequence Homology: monkey
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
10 mM sodium HEPES, pH 7.5, 150 mM NaCl, 0.1 mg/mL BSA, 50% glycerol
Preservative
0.02% Sodium azide

Target

Full Name
calcineurin binding protein 1
Introduction
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.
Entrez Gene ID
23523
UniProt ID
Q9Y6J0
Alternative Names
CAIN; PPP3IN; KB-318B8.7
Function
May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.
Biological Process
Cell surface receptor signaling pathway Source: UniProtKB
DNA replication-independent nucleosome assembly Source: UniProtKB
Cellular Location
Nucleus
PTM
Activated through PKC-mediated hyperphosphorylation. Phosphorylation by the DNA damage kinases ATM and CHK2 enhances ubiquitination.
Upon genotoxic stress, ubiquitination by the DCX(DDB2) E3 ubiquitin-protein ligase complex targets CABIN1 for proteasomal degradation, leading to the release of p53/TP53.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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