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Mouse Anti-CACNA1A Recombinant Antibody (CBYY-C0857) (CBMAB-C2293-YY)

This product is mouse antibody that recognizes CACNA1A. The antibody CBYY-C0857 can be used for immunoassay techniques such as: IP
See all CACNA1A antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBYY-C0857
Antibody Isotype
IgG2a
Application
IP

Basic Information

Specificity
Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Buffer
1 mg/mL
Preservative
PBS, pH 7.2, 50% glycerol
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
calcium channel BI-1
Entrez Gene ID
29716
UniProt ID
P27732
Alternative Names
Calcitonin Related Polypeptide Alpha; Calcitonin Gene-Related Peptide I; Alpha-Type CGRP; Calcitonin 1; Calcitonin; CGRP-I; CALC1; Calcitonin/Calcitonin-Related Polypeptide, Alpha;
Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity).
They are however insensitive to dihydropyridines (DHP).
Biological Process
Calcium ion import Source: GO_Central
Calcium ion transmembrane transport Source: UniProtKB
Calcium ion transport Source: GO_Central
Cell death Source: UniProtKB
Cellular response to amyloid-beta Source: ARUK-UCL
Chemical synaptic transmission Source: GO_Central
Membrane depolarization Source: Reactome
Modulation of chemical synaptic transmission Source: ARUK-UCL
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Regulation of insulin secretion Source: Reactome
Regulation of ion transmembrane transport Source: UniProtKB-KW
Response to amyloid-beta Source: ARUK-UCL
Cellular Location
Cell membrane
Involvement in disease
Spinocerebellar ataxia 6 (SCA6): Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA6 is an autosomal dominant cerebellar ataxia (ADCA), mainly caused by expansion of a CAG repeat in the coding region of CACNA1A. There seems to be a correlation between the repeat number and earlier onset of the disorder.
Migraine, familial hemiplegic, 1 (FHM1): A subtype of migraine with aura associated with ictal hemiparesis and, in some families, cerebellar ataxia and atrophy. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. Migraine with aura is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking.
Episodic ataxia 2 (EA2): An autosomal dominant disorder characterized by acetozolamide-responsive attacks of ataxia, migraine-like symptoms, interictal nystagmus, and cerebellar atrophy.
Developmental and epileptic encephalopathy 42 (DEE42): A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE42 inheritance is autosomal dominant.
Topology
Cytoplasmic: 1-98 aa
Helical: 99-117 aa
Extracellular: 118-135 aa
Helical: 136-155 aa
Cytoplasmic: 156-167 aa
Helical: 168-185 aa
Extracellular: 186-190 aa
Helical: 191-209 aa
Cytoplasmic: 210-228 aa
Helical: 229-248 aa
Extracellular: 249-335 aa
Helical: 336-360 aa
Cytoplasmic: 361-486 aa
Helical: 487-505 aa
Extracellular: 506-520 aa
Helical: 521-540 aa
Cytoplasmic: 541-548 aa
Helical: 549-567 aa
Extracellular: 568-577 aa
Helical: 578-596 aa
Cytoplasmic: 597-615 aa
Helical: 616-635 aa
Extracellular: 636-688 aa
Helical: 689-713 aa
Cytoplasmic: 714-1241 aa
Helical: 1242-1260 aa
Extracellular: 1261-1276 aa
Helical: 1277-1296 aa
Cytoplasmic: 1297-1308 aa
Helical: 1309-1327 aa
Extracellular: 1328-1338 aa
Helical: 1339-1357 aa
Cytoplasmic: 1358-1376 aa
Helical: 1377-1396 aa
Extracellular: 1397-1483 aa
Helical: 1484-1508 aa
Cytoplasmic: 1509-1563 aa
Helical: 1564-1592 aa
Extracellular: 1593-1597 aa
Helical: 1598-1617 aa
Cytoplasmic: 1618-1625 aa
Helical: 1626-1644 aa
Extracellular: 1645-1651 aa
Helical: 1652-1670 aa
Cytoplasmic: 1671-1689 aa
Helical: 1690-1709 aa
Extracellular: 1710-1781 aa
Helical: 1782-1806 aa
Cytoplasmic: 1807-2506 aa

Hidalgo, S., Campusano, J. M., & Hodge, J. J. (2021). The Drosophila ortholog of the schizophrenia-associated CACNA1A and CACNA1B voltage-gated calcium channels regulate memory, sleep and circadian rhythms. Neurobiology of Disease, 155, 105394.

Manickam, A. H., & Ramasamy, S. (2021). Mutations in the Voltage Dependent Calcium Channel CACNA1A (P/Q type alpha 1A subunit) Causing Neurological Disorders-An Overview. Neurology India, 69(4), 808.

Ohmori, I., Kobayashi, K., & Ouchida, M. (2020). Scn1a and Cacna1a mutations mutually alter their original phenotypes in rats. Neurochemistry International, 141, 104859.

Pan, R., Qi, X., Wang, F., Chong, Y., Li, X., & Chen, Q. (2019). Correlations of calcium voltage-gated channel subunit alpha1 A (CACNA1A) Gene Polymorphisms with Benign Paroxysmal Positional Vertigo. Medical science monitor: international medical journal of experimental and clinical research, 25, 946.

Cao-Pham, A. H., Hiong, K. C., Boo, M. V., Choo, C. Y., Wong, W. P., Chew, S. F., & Ip, Y. K. (2019). Calcium absorption in the fluted giant clam, Tridacna squamosa, may involve a homolog of voltage-gated calcium channel subunit α1 (CACNA1) that has an apical localization and displays light-enhanced protein expression in the ctenidium. Journal of Comparative Physiology B, 189(6), 693-706.

Algahtani, H., Shirah, B., Algahtani, R., Al-Qahtani, M. H., Abdulkareem, A. A., & Naseer, M. I. (2019). A novel mutation in CACNA1A gene in a Saudi female with episodic ataxia type 2 with no response to acetazolamide or 4-aminopyridine. Intractable & rare diseases research, 8(1), 67-71.

Petrovicova, A., Brozman, M., Kurca, E., Gobo, T., Dluha, J., Kalmarova, K., ... & Sivak, S. (2017). Novel missense variant of CACNA1A gene in a Slovak family with episodic ataxia type 2. Biomedical Papers, 161(1), 107-110.

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For research use only. Not intended for any clinical use.

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