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Mouse Anti-CACNB4 Recombinant Antibody (7E1) (CBMAB-1266-CN)

This product is a mouse antibody that recognizes CACNB4 of human. The antibody 7E1 can be used for immunoassay techniques such as: ELISA, WB.
See all CACNB4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7E1
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
CACNB4 (NP_000717.2, aa. 1-110) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Calcium Voltage-Gated Channel Auxiliary Subunit Beta 4
Introduction
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation.
Entrez Gene ID
UniProt ID
Alternative Names
EA5; EJM; CAB4; EIG9; EJM4; EJM6; CACNLB4
Function
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Biological Process
Chemical synaptic transmission Source: GO_Central
Membrane depolarization Source: Reactome
Neuromuscular junction development Source: GO_Central
Regulation of voltage-gated calcium channel activity Source: UniProtKB
Cellular Location
Cytosol; Cytoplasmic side of plasma membrane; Plasma membrane; Voltage-gated calcium channel complex; Synapse
Involvement in disease
Epilepsy, idiopathic generalized 9 (EIG9): A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain.
Juvenile myoclonic epilepsy 6 (EJM6): A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
Episodic ataxia 5 (EA5): A disorder characterized by episodes of vertigo and ataxia that last for several hours. Interictal examination show spontaneous downbeat and gaze-evoked nystagmus, mild dysarthria and truncal ataxia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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