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Mouse Anti-CACNG3 Recombinant Antibody (CBXC-0039) (CBMAB-C3195-CQ)

This product is a mouse antibody that recognizes CACNG3. The antibody CBXC-0039 can be used for immunoassay techniques such as: ELISA, WB.
See all CACNG3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0039
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
calcium channel, voltage-dependent, gamma subunit 3
Introduction
CACNG3 (Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 3) is a Protein Coding gene. Diseases associated with CACNG3 include Childhood Absence Epilepsy and Epilepsy, Idiopathic Generalized. Among its related pathways are Cardiac conduction and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include voltage-gated calcium channel activity. An important paralog of this gene is CACNG2.
Entrez Gene ID
10368
UniProt ID
O60359
Alternative Names
Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 3; Neuronal Voltage-Gated Calcium Channel Gamma-3 Subunit; Calcium Channel, Voltage-Dependent, Gamma Subunit 3; Transmembrane AMPAR Regulatory Protein Gamma-3; TARP Gamma-3;
Function
Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Biological Process
Calcium ion transport Source: UniProtKB
Neurotransmitter receptor internalization Source: GO_Central
Neurotransmitter receptor transport, postsynaptic endosome to lysosome Source: GO_Central
Positive regulation of AMPA receptor activity Source: Ensembl
Positive regulation of synaptic transmission, glutamatergic Source: GO_Central
Postsynaptic neurotransmitter receptor diffusion trapping Source: GO_Central
Protein localization Source: UniProtKB
Protein targeting Source: UniProtKB
Regulation of AMPA receptor activity Source: UniProtKB
Transmission of nerve impulse Source: GO_Central
Cellular Location
Membrane. Displays a somatodendritic localization and is excluded from axons in neurons.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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