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Mouse Anti-CaMK1D Recombinant Antibody (2C6) (CBMAB-C4806-LY)

This product is antibody recognizes CaMK1D. The antibody 2C6 immunoassay techniques such as: ICC/IF, IHC, IHC-P, WB.
See all CaMK1D antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C6
Antibody Isotype
IgG1
Application
ICC/IF, IHC, IHC-P, WB

Basic Information

Immunogen
Full length human recombinant protein of human CAMK1D (NP_065130) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
calcium/calmodulin-dependent protein kinase ID
Introduction
This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]
Entrez Gene ID
57118
UniProt ID
Q8IU85
Alternative Names
Calcium/Calmodulin Dependent Protein Kinase ID; CaM Kinase I Delta; CaM Kinase ID; CaM-KI Delta; EC 2.7.11.17; CaMKI Delta; CaMKID; CKLiK;
Function
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.
Biological Process
Inflammatory response Source: UniProtKB-KW
Negative regulation of apoptotic process Source: Ensembl
Nervous system development Source: UniProtKB-KW
Peptidyl-serine phosphorylation Source: GO_Central
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of CREB transcription factor activity Source: UniProtKB
Positive regulation of neuron projection development Source: UniProtKB
Positive regulation of neutrophil chemotaxis Source: UniProtKB
Positive regulation of phagocytosis Source: UniProtKB
Positive regulation of respiratory burst Source: UniProtKB
Regulation of dendrite development Source: UniProtKB
Regulation of granulocyte chemotaxis Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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