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Mouse Anti-CAMP Recombinant Antibody (CBYJL-188) (CBMAB-L0268-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Cathelicidin Antimicrobial Peptide (CAMP). The antibody can be used for immunoassay techniques, such as IF, WB.
See all CAMP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-188
Antibody Isotype
IgG1, κ
Application
IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cathelicidin Antimicrobial Peptide
Introduction
Diseases associated with CAMP include Mycobacterium Marinum and Rosacea. Among its related pathways are Defensins and Innate Immune System.
Entrez Gene ID
820
UniProt ID
P49913
Alternative Names
Cathelicidin Antimicrobial Peptide; 18 KDa Cationic Antimicrobial Protein; CAP-18; FALL39; CAP18; FALL-39
Function
Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.
Biological Process
Antibacterial humoral response Source: UniProtKB
Antifungal humoral response Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Chronic inflammatory response Source: UniProtKB
Cytolysis by host of symbiont cells Source: UniProtKB
Defense response to bacterium Source: MGI
Defense response to Gram-negative bacterium Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
Innate immune response Source: UniProtKB
Innate immune response in mucosa Source: UniProtKB
Killing by host of symbiont cells Source: CACAO
Modulation of process of other organism Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of interleukin-8 production Source: UniProtKB
Response to yeast Source: UniProtKB
Cellular Location
Secreted
PTM
The N-terminus is blocked.

Hochberg, A., Patz, M., Karrasch, T., Schäffler, A., & Schmid, A. (2021). Serum levels and adipose tissue gene expression of cathelicidin antimicrobial peptide (CAMP) in obesity and during weight loss. Hormone and Metabolic Research, 53(03), 169-177.

Karrasch, T., Höpfinger, A., Schäffler, A., & Schmid, A. (2021). The adipokine C1q/TNF-related protein-3 (CTRP-3) inhibits Toll-like receptor (TLR)-induced expression of Cathelicidin antimicrobial peptide (CAMP) in adipocytes. Cytokine, 148, 155663.

Wang, G., Li, Y., Yang, G., Yang, T., He, L., & Wang, Y. (2021). Cathelicidin antimicrobial peptide (CAMP) gene promoter methylation induces chondrocyte apoptosis. Human Genomics, 15(1), 1-10.

Lowry, M. B., Guo, C., Zhang, Y., Fantacone, M. L., Logan, I. E., Campbell, Y., ... & Gombart, A. F. (2020). A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression. The Journal of steroid biochemistry and molecular biology, 198, 105552.

Chen, X., Ji, S., Si, J., Zhang, X., Wang, X., Guo, Y., & Zou, X. (2020). Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis. Molecular Medicine Reports, 22(6), 5243-5250.

Febriza, A., Hatta, M., Natzir, R., Kasim, V. N., & Idrus, H. H. (2019). Activity of antimicrobial peptide; cathelicidin, on bacterial infection. The Open Biochemistry Journal, 13(1).

Li, Y., Østerhus, S., & Johnsen, I. B. (2018). Human metapneumovirus infection inhibits cathelicidin antimicrobial peptide expression in human macrophages. Frontiers in immunology, 9, 902.

Thomi, R., Schlapbach, C., Yawalkar, N., Simon, D., Yerly, D., & Hunger, R. E. (2018). Elevated levels of the antimicrobial peptide LL‐37 in hidradenitis suppurativa are associated with a Th1/Th17 immune response. Experimental dermatology, 27(2), 172-177.

Chen, X., Qi, G., Qin, M., Zou, Y., Zhong, K., Tang, Y., ... & Zou, X. (2017). DNA methylation directly downregulates human cathelicidin antimicrobial peptide gene (CAMP) promoter activity. Oncotarget, 8(17), 27943.

Barksdale, S. M., Hrifko, E. J., & van Hoek, M. L. (2017). Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae. Developmental & Comparative Immunology, 70, 135-144.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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