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Mouse Anti-CBLC Recombinant Antibody (CBXC-2159) (CBMAB-C5878-CQ)

This product is a mouse antibody that recognizes CBLC. The antibody CBXC-2159 can be used for immunoassay techniques such as: WB, FC.
See all CBLC antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2159
Antibody Isotype
IgG2b
Application
WB, FC

Basic Information

Immunogen
Recombinant protein corresponding to amino acids 244-474 of human CBLC (NP_036248) produced in E. coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cas-Br-M (murine) ecotropic retroviral transforming sequence c
Introduction
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
23624
UniProt ID
Q9ULV8
Alternative Names
Cbl Proto-Oncogene C; Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence C; Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence C; Cbl Proto-Oncogene C, E3 Ubiquitin Protein Ligase; RING-Type E3 Ubiquitin Transferase CBL-C; Signal Transduction Protein CBL-C; SH3-Binding Protein CBL-3; SH3-Binding Protein CBL-C; RING Finger Protein 57;
Function
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
Biological Process
Cell surface receptor signaling pathway Source: InterPro
Negative regulation of epidermal growth factor-activated receptor activity Source: BHF-UCL
Negative regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of MAP kinase activity Source: BHF-UCL
Protein ubiquitination Source: BHF-UCL
Signal transduction Source: GO_Central
Ubiquitin-dependent protein catabolic process Source: BHF-UCL
Cellular Location
Plasma membrane; Membrane raft
PTM
Phosphorylated on multiple tyrosine residues by SRC. Isoform 1, but not isoform 2, is phosphorylated on tyrosines by EGFR.
Autoubiquitinated when phosphorylated at Tyr-341, enhanced by SRC; suggesting proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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