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Mouse Anti-CCDC101 Antibody (1D10) (CBMAB-0209-YC)

Provided herein are mouse monoclonal antibodies against Human CCDC101. The antibody clone 1D10 can be used for immunoassay techniques, such as ELISA, IP and WB.
See all CCDC101 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D10
Antibody Isotype
IgG1
Application
ELISA, IP, WB

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Coiled-coil domain containing 101
Introduction
CCDC101 (coiled-coil domain containing 101) is a 293 amino acid nuclear protein that plays a role in transcriptional regulation by functioning as a subunit of two histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases.
Entrez Gene ID
112869
UniProt ID
Q96ES7
Alternative Names
CCDC101; FLJ32446; TDRD29
Function
Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293).
SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293).
In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016).
Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581).
Biological Process
Establishment of protein localization to chromatin Source: UniProtKB
Histone acetylation Source: UniProtKB
Histone H3 acetylation Source: BHF-UCL
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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