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Rat Anti-CCL14 Recombinant Antibody (MM0138-4H14) (CBMAB-C9799-LY)

The product is antibody recognizes CCL14. The antibody MM0138-4H14 immunoassay techniques such as: WB, Blocking/Neutralization.
See all CCL14 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
MM0138-4H14
Antibody Isotype
IgG2
Application
WB, Blocking/Neutralization

Basic Information

Immunogen
Human CCL14
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
chemokine (C-C motif) ligand 14
Introduction
CCL14 (C-C Motif Chemokine Ligand 14) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL3.
Entrez Gene ID
6358
UniProt ID
Q16627
Alternative Names
C-C Motif Chemokine Ligand 14; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 14; Chemokine (C-C Motif) Ligand 14; Small-Inducible Cytokine A14; Chemokine CC-1/CC-3; HCC-1(1-74); HCC-1/HCC-3; SCYA14; NCC-2; NCC2; Hemofiltrate CC Chemokine 1; C-C Motif Chemokine 14;
Function
Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
Biological Process
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Cellular Location
Secreted
PTM
The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.
HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.

Massoth, C., Küllmar, M., Enders, D., Kellum, J. A., Forni, L. G., Meersch, M., ... & Rossaint, J. (2021). Comparison of CC motif chemokine ligand 14 with other biomarkers for adverse kidney events after cardiac surgery. The Journal of Thoracic and Cardiovascular Surgery.

Li, N., Liang, X., Li, J., Zhang, D., Li, T., & Guo, Z. (2021). CC motif chemokine ligand 14 inhibited colon cancer cell proliferation and invasion through suppressing M2 polarization of tumor-associated macrophages. Histology and Histopathology, 18348-18348.

Bagshaw, S. M., Al-Khafaji, A., Artigas, A., Davison, D., Haase, M., Lissauer, M., ... & Kellum, J. A. (2021). External validation of urinary C–C motif chemokine ligand 14 (CCL14) for prediction of persistent acute kidney injury. Critical Care, 25(1), 1-8.

Yan, G., Li, S., Yue, M., Li, C., & Kang, Z. (2021). Lysine demethylase 5B suppresses CC chemokine ligand 14 to promote progression of colorectal cancer through the Wnt/β-catenin pathway. Life Sciences, 264, 118726.

Mamoor, S. (2021). Differential expression of CCL14 in cancer of the vulva.

Gu, Y., Li, X., Bi, Y., Zheng, Y., Wang, J., Li, X., ... & Huang, Y. (2020). CCL14 is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma. Aging (Albany NY), 12(1), 784.

Cai, Y., Ling, Y., Huang, L., Huang, H., Chen, X., Xiao, Y., ... & Chen, J. (2020). C‑C motif chemokine 14 as a novel potential biomarker for predicting the prognosis of epithelial ovarian cancer. Oncology letters, 19(4), 2875-2883.

Zhu, M., Xu, W., Wei, C., Huang, J., Xu, J., Zhang, Y., ... & Liang, C. (2019). CCL14 serves as a novel prognostic factor and tumor suppressor of HCC by modulating cell cycle and promoting apoptosis. Cell death & disease, 10(11), 1-10.

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For research use only. Not intended for any clinical use.

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