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Rabbit Anti-CCL18 Recombinant Antibody (CBFYC-0946) (CBMAB-C1002-FY)

This product is rabbit antibody that recognizes CCL18. The antibody CBFYC-0946 can be used for immunoassay techniques such as: ELISA.
See all CCL18 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYC-0946
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human CCL18PARCMIP-4 Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
Introduction
CCL18 (C-C Motif Chemokine Ligand 18) is a Protein Coding gene. Diseases associated with CCL18 include Gaucher's Disease and Pulmonary Fibrosis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL3.
Entrez Gene ID
UniProt ID
Alternative Names
C-C Motif Chemokine Ligand 18; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 18, Pulmonary And Activation-Regulated; Chemokine (C-C Motif) Ligand 18 (Pulmonary And Activation-Regulated); Alternative Macrophage Activation-Associated CC Chemokine 1; Pulmonary And Activation-Regulated Chemokine; Macrophage Inflammatory Protein 4; Dendritic Cell Chemokine 1; CC Chemokine PARC; SCYA18; AMAC-1; DC-CK1; AMAC1; DCCK1
Function
Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cell communication Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
The Cys-30/Cys-54 disulfide bond is required for activity.

Aravind, A., Palollathil, A., Rex, D. A. B., Kumar, K. M. K., Vijayakumar, M., Shetty, R., ... & Raju, R. (2021). A multi-cellular molecular signaling and functional network map of C–C motif chemokine ligand 18 (CCL18): a chemokine with immunosuppressive and pro-tumor functions. Journal of Cell Communication and Signaling, 1-8.

Sun, Z., Du, C., Xu, P., & Miao, C. (2019). Surgical trauma‐induced CCL18 promotes recruitment of regulatory T cells and colon cancer progression. Journal of cellular physiology, 234(4), 4608-4616.

Ma, L., Wang, H., Li, Z., Geng, X., & Li, M. (2019). Chemokine (CC motif) ligand 18 is highly expressed in glioma tissues and promotes invasion of glioblastoma cells. Journal of cancer research and therapeutics, 15(2), 358.

Huang, H., Li, J., Hu, W. J., Chen, C., Luo, H. Q., Tang, X. D., ... & Li, X. Y. (2019). The serum level of CC chemokine ligand 18 correlates with the prognosis of non-small cell lung cancer. The International journal of biological markers, 34(2), 156-162.

Song, H., Tao, Y., Ni, N., Zhou, X., Xiong, J., Zeng, X., ... & Sun, J. (2018). miR-128 targets the CC chemokine ligand 18 gene (CCL18) in cutaneous malignant melanoma progression. Journal of dermatological science, 91(3), 317-324.

Orekhov, A. N., Nikiforov, N. G., Elizova, N. V., Korobov, G. A., Aladinskaya, A. V., Sobenin, I. A., & Bobryshev, Y. V. (2018). Tumor necrosis factor-α and CC motif chemokine ligand 18 associate with atherosclerotic lipid accumulation in situ and in vitro. Current pharmaceutical design, 24(24), 2883-2889.

Huang, H., Li, J., Hu, W. J., Chen, M. H., Chen, S. S., Chen, C., ... & Li, X. Y. (2018). Positive expression of chemokine (CC Motif) ligand 18 and prognosis in cancer: A meta-analysis. Journal of BU ON.: official journal of the Balkan Union of Oncology, 23(4), 1185-1194.

Yuan, L., Wan, J., Huang, C., Liang, J., Liu, M., Yue, C., & Li, L. (2018). Evaluation of serum CCL18 as a potential biomarker for ovarian cancer. Cancer Biomarkers, 21(1), 97-104.

Bo, S., Donghao, S., Guangqi, K., & Ye, T. (2018). CC Chemokine Ligand 18 Promotes Cell Proliferation and Metastasis of Urothelial Carcinoma via Activating PI3K/mTOR Signaling in Patient with Renal Transplantation. Urologia internationalis, 101(4), 450-458.

Wang, H., Liang, X., Li, M., Tao, X., Tai, S., Fan, Z., ... & Xia, J. (2017). Chemokine (CC motif) ligand 18 upregulates Slug expression to promote stem‐cell like features by activating the mammalian target of rapamycin pathway in oral squamous cell carcinoma. Cancer science, 108(8), 1584-1593.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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