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Rat Anti-CCL19 (AA 26-107) Recombinant Antibody (CBFYM-0912) (CBMAB-M1060-FY)

This product is rat antibody that recognizes CCL19. The antibody CBFYM-0912 can be used for immunoassay techniques such as: ELISA(Det), Neut, WB.
See all CCL19 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYM-0912
Antibody Isotype
IgG2a
Application
ELISA(Det), Neut, WB

Basic Information

Immunogen
Recombinant mouse CCL19/MIP-3 beta Gly26-Val107-Leu-Glu (Ser108LeuGlu)
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 5% trehalose
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 26-107

Target

Full Name
C-C Motif Chemokine Ligand 19
Introduction
CCL19 is a Protein Coding gene. Diseases associated with CCL19 include Lymphoproliferative Syndrome 2 and Leukemia, Chronic Lymphocytic. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology annotations related to this gene include chemokine activity and CCR10 chemokine receptor binding.
Entrez Gene ID
6363
UniProt ID
Q99731
Alternative Names
C-C Motif Chemokine Ligand 19; CK Beta-11; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 19; Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine; Macrophage Inflammatory Protein 3-Beta; Chemokine (C-C Motif) Ligand 19; Small-Inducible Cytokine A19; Beta Chemokine Exodus-3; CC Chemokine Ligand 19; EBI1-Ligand Chemokine; MIP-3-Beta
Function
May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Biological Process
Activation of JUN kinase activity Source: BHF-UCL
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell communication Source: ProtInc
Cell maturation Source: BHF-UCL
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Cellular response to virus Source: UniProtKB
Chemokine-mediated signaling pathway Source: GO_Central
Cytokine-mediated signaling pathway Source: Reactome
Dendritic cell chemotaxis Source: BHF-UCL
Establishment of T cell polarity Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Immunological synapse formation Source: BHF-UCL
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Mature conventional dendritic cell differentiation Source: BHF-UCL
Monocyte chemotaxis Source: GO_Central
Myeloid dendritic cell chemotaxis Source: BHF-UCL
Negative regulation of dendritic cell apoptotic process Source: BHF-UCL
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell motility Source: BHF-UCL
Positive regulation of chemotaxis Source: BHF-UCL
Positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
Positive regulation of dendritic cell dendrite assembly Source: BHF-UCL
Positive regulation of endocytosis Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of glycoprotein biosynthetic process Source: BHF-UCL
Positive regulation of GTPase activity Source: BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
Positive regulation of interleukin-12 production Source: BHF-UCL
Positive regulation of interleukin-1 beta production Source: BHF-UCL
Positive regulation of JNK cascade Source: BHF-UCL
Positive regulation of neutrophil chemotaxis Source: BHF-UCL
Positive regulation of NIK/NF-kappaB signaling Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
Positive regulation of protein kinase activity Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of receptor-mediated endocytosis Source: BHF-UCL
Positive regulation of T cell proliferation Source: BHF-UCL
Positive regulation of T-helper 1 cell differentiation Source: BHF-UCL
Positive regulation of tumor necrosis factor production Source: BHF-UCL
Regulation of cell projection assembly Source: BHF-UCL
Release of sequestered calcium ion into cytosol Source: BHF-UCL
Response to nitric oxide Source: BHF-UCL
Response to prostaglandin E Source: BHF-UCL
Response to virus Source: ProtInc
T cell costimulation Source: BHF-UCL
Cellular Location
Secreted

Hayashi, M., Iwashita, M., Nishimura, Y., Shinjo, T., Sano, T., Yamashita, A., ... & Nishimura, F. (2021). Adipose-specific CC motif chemokine ligand (CCL) 19 overexpression drives the mice to both insulin resistance and weight gain. BMJ Open Diabetes Research and Care, 9(1), e001871.

Wei, W., Wang, J., Min, Q., Jia, Z., Chen, K., Feng, H., & Zou, J. (2021). CCL19 variants mediate chemotactic response via CCR7 in grass carp Ctenopharyngodon idella. Developmental & Comparative Immunology, 122, 104127.

Guo, R., Chen, Y., Liu, L., Wen, J., Yang, H., Zhu, Y., ... & Long, H. (2021). Nerve growth factor enhances tooth mechanical hyperalgesia through CC chemokine ligand 19 in rats. Frontiers in neurology, 12.

Mastini, C., Campisi, M., Costa, C., Ambrogio, C., Germena, G., Peola, S., ... & Chiarle, R. (2021). Abstract LT018: The perivascular niche protects ALK+ lymphoma cells from ALK inhibition through the CCL19/21-CCR7 axis.

Iida, Y., Yoshikawa, R., Murata, A., Kotani, H., Kazuki, Y., Oshimura, M., ... & Harada, M. (2020). Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells. Journal for immunotherapy of cancer, 8(2).

Balnis, J., Adam, A. P., Chopra, A., Chieng, H. C., Feustel, P. J., Overmyer, K. A., ... & Jaitovich, A. (2020). Higher plasma levels of Chemokine CCL19 are associated with poor SARS-CoV-2 acute respiratory distress syndrome (ARDS) outcomes. MedRxiv.

Zhou, R., Sun, J., He, C., Huang, C., & Yu, H. (2020). CCL19 suppresses gastric cancer cell proliferation, migration, and invasion through the CCL19/CCR7/AIM2 pathway. Human cell, 33(4), 1120-1132.

Yan, Y., Chen, R., Wang, X., Hu, K., Huang, L., Lu, M., & Hu, Q. (2019). CCL19 and CCR7 expression, signaling pathways, and adjuvant functions in viral infection and prevention. Frontiers in cell and developmental biology, 7, 212.

Liu, L., Zhao, L., Yang, Y., Gao, J., Hu, C., Guo, B., & Zhu, B. (2018). Cytotoxic chemotherapy reduces T cell trafficking to the spleen by downregulating the expression of C‑C motif chemokine ligand 21 and C‑C motif chemokine ligand 19. Oncology letters, 16(4), 5013-5019.

Zhao, J., Wang, Y., Wu, X., Tong, P., Yue, Y., Gao, S., ... & Huang, J. (2018). Inhibition of CCL19 benefits non‑alcoholic fatty liver disease by inhibiting TLR4/NF‑κB‑p65 signaling. Molecular medicine reports, 18(5), 4635-4642.

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For research use only. Not intended for any clinical use.

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