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Mouse Anti-CCL2 Recombinant Antibody (CBXC-0115) (CBMAB-C3354-CQ)

This product is a mouse antibody that recognizes CCL2. The antibody CBXC-0115 can be used for immunoassay techniques such as: ELISA, Neut, WB.
See all CCL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0115
Antibody Isotype
IgG1, κ
Application
ELISA, Neut, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 40% glycerol
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-C Motif Chemokine Ligand 2
Introduction
CCL2 (C-C Motif Chemokine Ligand 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with CCL2 include Neural Tube Defects and Human Immunodeficiency Virus Type 1. Among its related pathways are Ectoderm Differentiation and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase activity and heparin binding. An important paralog of this gene is CCL7.
Entrez Gene ID
6347
UniProt ID
P13500
Alternative Names
C-C Motif Chemokine Ligand 2; Monocyte Chemotactic And Activating Factor; Monocyte Secretory Protein JE; Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1; Homologous To Mouse Sig-Je); Small Inducible Cytokine Subfamily A (Cys-Cys); Member 2; Monocyte Chemoattractant Protein-1; Chemokine (C-C Motif) Ligand 2; Monocyte Chemotactic Protein 1; Small-Inducible Cytokine A2; SCYA2; MCP-1;
Function
Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171).
Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439).
Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247).
May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690).
Biological Process
Angiogenesis Source: BHF-UCL
Animal organ morphogenesis Source: ProtInc
Astrocyte cell migration Source: BHF-UCL
Cell adhesion Source: ProtInc
Cell surface receptor signaling pathway Source: ProtInc
Cellular homeostasis Source: BHF-UCL
Cellular response to fibroblast growth factor stimulus Source: UniProtKB
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to lipopolysaccharide Source: BHF-UCL
Cellular response to organic cyclic compound Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: BHF-UCL
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Helper T cell extravasation Source: BHF-UCL
Humoral immune response Source: ProtInc
Inflammatory response Source: UniProtKB
Lipopolysaccharide-mediated signaling pathway Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Macrophage chemotaxis Source: BHF-UCL
MAPK cascade Source: UniProtKB
Monocyte chemotaxis Source: BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycle Source: BHF-UCL
Negative regulation of glial cell apoptotic process Source: UniProtKB
Negative regulation of natural killer cell chemotaxis Source: UniProtKB
Negative regulation of neuron apoptotic process Source: UniProtKB
Negative regulation of vascular endothelial cell proliferation Source: BHF-UCL
Neutrophil chemotaxis Source: GO_Central
PERK-mediated unfolded protein response Source: Reactome
Positive regulation of apoptotic cell clearance Source: BHF-UCL
Positive regulation of calcium ion import Source: BHF-UCL
Positive regulation of endothelial cell apoptotic process Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
Positive regulation of NMDA glutamate receptor activity Source: ARUK-UCL
Positive regulation of synaptic transmission, glutamatergic Source: UniProtKB
Positive regulation of T cell activation Source: BHF-UCL
Protein kinase B signaling Source: UniProtKB
Protein phosphorylation Source: ProtInc
Receptor signaling pathway via JAK-STAT Source: ProtInc
Regulation of cell shape Source: UniProtKB
Response to bacterium Source: BHF-UCL
Sensory perception of pain Source: UniProtKB
Signal transduction Source: ProtInc
Viral genome replication Source: ProtInc
Cellular Location
Secreted
PTM
Processing at the N-terminus can regulate receptor and target cell selectivity (PubMed:8627182). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (PubMed:8627182).
N-Glycosylated.

Dommel, S., & Blüher, M. (2021). Does CC Motif Chemokine Ligand 2 (CCL2) Link Obesity to a Pro-Inflammatory State?. International Journal of Molecular Sciences, 22(3), 1500.

Schettini, I. V. G., Faria, D. V., Nogueira, L. S., Otoni, A., Silva, A. C. S., & Rios, D. R. A. (2021). Renin angiotensin system molecules and chemokine (CC motif) ligand 2 (CCL2) in chronic kidney disease patients. Brazilian Journal of Nephrology.

Li, M., Chen, Y., Zhang, Y., Li, D., & Liu, J. (2020). Correlation between monocyte chemoattractant protein-1/chemokine (CC motif) ligand 2 and coronary plaque characteristics. Experimental Biology and Medicine, 245(15), 1335-1343.

Iwamoto, H., Izumi, K., & Mizokami, A. (2020). Is the CC Motif Ligand 2–CC Chemokine Receptor 2 Axis a Promising Target for Cancer Therapy and Diagnosis?. International Journal of Molecular Sciences, 21(23), 9328.

Hernández-Aguilera, A., Fibla, M., Cabré, N., Luciano-Mateo, F., Camps, J., Fernández-Arroyo, S., ... & Joven, J. (2020). Chemokine (CC motif) ligand 2 and coronary artery disease: tissue expression of functional and atypical receptors. Cytokine, 126, 154923.

Luciano-Mateo, F., Cabré, N., Baiges-Gaya, G., Fernández-Arroyo, S., Hernández-Aguilera, A., Rodríguez-Tomàs, E. E., ... & Joven, J. (2020). Systemic overexpression of CC motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging. Aging (Albany NY), 12(20), 20001.

Li, L., Lou, W., Li, H., & Zhu, Y. (2020). Upregulated CC motif chemokine ligand 2 promotes ischemic stroke via chemokine signaling pathway. Annals of Vascular Surgery, 68, 476-486.

Kimura, A., Yoshikura, N., Hayashi, Y., & Inuzuka, T. (2018). Cerebrospinal fluid CC motif chemokine ligand 2 correlates with brain atrophy and cognitive impairment in Alzheimer’s disease. Journal of Alzheimer's Disease, 61(2), 581-588.

Yoshida, H., Imaizumi, T., Matsumiya, T., Seya, K., Kawaguchi, S., & Tanaka, H. (2018). Gnetin C suppresses double-stranded RNA-induced CC motif chemokine ligand 2 (CCL2) and CCL5 production by inhibiting Toll-like receptor 3 signaling pathway. Biomedical Research, 39(5), 231-240.

Lai, C., Wang, K., Zhao, Z., Zhang, L., Gu, H., Yang, P., & Wang, X. (2017). CC motif chemokine ligand 2 (CCL2) mediates acute lung injury induced by lethal influenza H7N9 virus. Frontiers in microbiology, 8, 587.

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For research use only. Not intended for any clinical use.

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