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Rat Anti-CCL25 Recombinant Antibody (14L108) (CBMAB-C3073-LY)

This product is antibody recognizes CCL25. The antibody 14L108 immunoassay techniques such as: IHC, Neutralization, WB.
See all CCL25 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
14L108
Antibody Isotype
IgG2
Application
IHC, Neutralization, WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse CCL-25
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-C Motif Chemokine Ligand 25
Introduction
CCL25 (C-C Motif Chemokine Ligand 25) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include hormone activity and chemokine receptor binding.
Entrez Gene ID
20300
UniProt ID
O35903
Function
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell chemotaxis Source: UniProtKB
Cell surface receptor signaling pathway Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: UniProtKB
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Negative regulation of leukocyte tethering or rolling Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell-matrix adhesion Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Cellular Location
Secreted

Zhang, L. L., Li, C. H., & Chen, J. (2021). Molecular characterization and chemotaxis assay of a CC motif chemokine ligand 25 from Japanese sea bass (Lateolabrax japonicus). Fish & Shellfish Immunology.

Airaksinen, L., Cerqueira, J. X., Huhtala, H., Saavalainen, P., Yohannes, D. A., Mäki, M., ... & Lindfors, K. (2021). Dissecting the contribution of single nucleotide polymorphisms in CCR9 and CCL25 genomic regions to the celiac disease phenotype. Journal of Translational Autoimmunity, 4, 100128.

Li, J., Muhammad, J., Xie, T., Sun, J., Lei, Y., Wei, Z., ... & Zhang, Q. (2021). LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25. Molecular Immunology, 140, 267-275.

Niu, Y., Tang, D., Fan, L., Gao, W., & Lin, H. (2020). CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner. Experimental and therapeutic medicine, 19(6), 3571-3580.

Liu, M. Z., Chen, S. M., Xu, Y., Kong, Y. G., Deng, Y. Q., Li, F., & Tao, Z. Z. (2020). Increased Expressions and Roles of CC Chemokine Ligand 21 and CC Chemokine Ligand 25 in Chronic Rhinosinusitis with Nasal Polyps. International archives of allergy and immunology, 181(3), 159-169.

Atanes, P., Lee, V., Huang, G. C., & Persaud, S. J. (2020). The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes. Metabolism, 113, 154394.

Ringe, J., Hemmati‐Sadeghi, S., Fröhlich, K., Engels, A., Reiter, K., Dehne, T., & Sittinger, M. (2019). CCL25‐Supplemented Hyaluronic Acid Attenuates Cartilage Degeneration in a Guinea Pig Model of Knee Osteoarthritis. Journal of Orthopaedic Research®, 37(8), 1723-1729.

Stich, S., Möller, A., Cabraja, M., Krüger, J. P., Hondke, S., Endres, M., ... & Sittinger, M. (2018). Chemokine CCL25 induces migration and extracellular matrix production of anulus fibrosus-derived cells. International journal of molecular sciences, 19(8), 2207.

Wang, C., Liu, Z., Xu, Z., Wu, X., Zhang, D., Zhang, Z., & Wei, J. (2018). The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells. Oncology letters, 16(2), 2071-2077.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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