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Mouse Anti-CCL8 Recombinant Antibody (CBFYC-1001) (CBMAB-C1058-FY)

This product is mouse antibody that recognizes CCL8. The antibody CBFYC-1001 can be used for immunoassay techniques such as: Neut, WB.
See all CCL8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1001
Antibody Isotype
IgG1
Application
Neut, WB

Basic Information

Immunogen
Recombinant protein corresponding to human CCL-8
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-C Motif Chemokine Ligand 8
Introduction
CCL8 (C-C Motif Chemokine Ligand 8) is a Protein Coding gene. Diseases associated with CCL8 include Diffuse Gastric Cancer. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase activity and chemokine activity. An important paralog of this gene is CCL11.
Entrez Gene ID
UniProt ID
Alternative Names
C-C Motif Chemokine Ligand 8; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 8 (Monocyte Chemotactic Protein 2); Monocyte Chemoattractant Protein 2; Chemokine (C-C Motif) Ligand 8; Monocyte Chemotactic Protein 2; Small-Inducible Cytokine A8; SCYA10
Function
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Calcium ion transport Source: UniProtKB
Cell-cell signaling Source: UniProtKB
Cellular calcium ion homeostasis Source: UniProtKB
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Eosinophil chemotaxis Source: GO_Central
Exocytosis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Negative regulation by host of viral genome replication Source: ARUK-UCL
Negative regulation of leukocyte proliferation Source: Ensembl
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of leukocyte migration Source: Ensembl
Response to virus Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Lan, K. F., Shen, Y. Q., Li, Y., Ling, C. L., Gong, Y. M., Xia, S. C., ... & Ding, X. (2021). Chemokine CC motif ligand 8 in periodontal ligament during orthodontic tooth movement. Archives of Oral Biology, 123, 104996.

Amador‐Martínez, I., García‐Ballhaus, J., Buelna‐Chontal, M., Cortés‐González, C., Massó, F., Jaisser, F., & Barrera‐Chimal, J. (2021). Early inflammatory changes and CC chemokine ligand‐8 upregulation in the heart contribute to uremic cardiomyopathy. The FASEB Journal, 35(8), e21761.

Baltaeva, Y. Y., Yuldasheva, М. Т., Palvanova, М. S., & Hoshimov, M. S. (2021). The Specific Role of CCL8 Chemokine in Atherosclerosis. International Journal of Multicultural and Multireligious Understanding, 8(6), 205-211.

Igarashi, K., Hori, T., Yamamoto, M., Sohma, H., Suzuki, N., Tsutsumi, H., ... & Kokai, Y. (2021). CCL8 deficiency in the host abrogates early mortality of acute graft-versus-host disease in mice with dysregulated IL-6 expression. Experimental Hematology.

Xue, S., Tang, H., Zhao, G., Fang, C., Shen, Y., Yan, D., ... & Guo, D. (2021). C–C motif ligand 8 promotes atherosclerosis via NADPH oxidase 2/reactive oxygen species-induced endothelial permeability increase. Free Radical Biology and Medicine, 167, 181-192.

Kim, E. S., Nam, S. M., Song, H. K., Lee, S., Kim, K., Lim, H. K., ... & Moon, A. (2021). CCL8 mediates crosstalk between endothelial colony forming cells and triple-negative breast cancer cells through IL-8, aggravating invasion and tumorigenicity. Oncogene, 40(18), 3245-3259.

Zhang, X., Chen, L., Dang, W. Q., Cao, M. F., Xiao, J. F., Lv, S. Q., ... & Bian, X. W. (2020). CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling. Laboratory Investigation, 100(4), 619-629.

Dai, S., Zhang, J., & Xu, Z. (2020). Silencing CCL8 inhibited the proliferation and migration of PDGF-BB-stimulated human aortic smooth muscle cells. Bioscience, Biotechnology, and Biochemistry, 84(8), 1585-1593.

Ge, B., Li, J., Wei, Z., Sun, T., Song, Y., & Khan, N. U. (2017). Functional expression of CCL8 and its interaction with chemokine receptor CCR3. BMC immunology, 18(1), 1-8.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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