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Mouse Anti-CCM2 Recombinant Antibody (CBFYC-1010) (CBMAB-C1067-FY)

This product is mouse antibody that recognizes CCM2. The antibody CBFYC-1010 can be used for immunoassay techniques such as: IF, IHC, WB.
See all CCM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1010
Antibody Isotype
IgG1
Application
IF, IHC, WB

Basic Information

Immunogen
Full-length recombinant protein of human CCM2 (NP_113631) produced in HEK293T cells
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CCM2 Scaffolding Protein
Introduction
CCM2 (CCM2 Scaffolding Protein) is a Protein Coding gene. Diseases associated with CCM2 include Cerebral Cavernous Malformations 2 and Cavernous Hemangioma. Among its related pathways are p38 MAPK signaling pathway (Pathway Interaction Database) and Regulation of p38-alpha and p38-beta. An important paralog of this gene is CCM2L.
Entrez Gene ID
83605
UniProt ID
Q9BSQ5
Alternative Names
CCM2 Scaffolding Protein; Malcavernin; Cerebral Cavernous Malformation 2; Osmosensing Scaffold For MEKK3; C7orf22; Cerebral Cavernous Malformations 2 Protein; Chromosome 7 Open Reading Frame 22; PP10187; OSM
Function
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity).
May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
Biological Process
Blood vessel endothelial cell differentiation Source: Ensembl
Cell-cell junction organization Source: Ensembl
Endothelial cell development Source: Ensembl
Endothelial tube morphogenesis Source: MGI
Inner ear development Source: Ensembl
Integrin-mediated signaling pathway Source: UniProtKB
In utero embryonic development Source: Ensembl
Multicellular organism growth Source: Ensembl
Pericardium development Source: Ensembl
Stress-activated MAPK cascade Source: UniProtKB
Vasculogenesis Source: UniProtKB
Venous blood vessel morphogenesis Source: Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Cerebral cavernous malformations 2 (CCM2): A congenital vascular anomaly of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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