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Mouse Anti-CCNB1 Recombinant Antibody (CBYY-C1108) (CBMAB-C2545-YY)

This product is mouse antibody that recognizes CCNB1. The antibody CBYY-C1108 can be used for immunoassay techniques such as: WB, IHC-P, FC, S-ELISA
See all CCNB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C1108
Antibody Isotype
IgG1
Application
WB, IHC-P, FC, S-ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Tissue culture supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cyclin B1
Entrez Gene ID
891
UniProt ID
P14635
Alternative Names
C-C Motif Chemokine Receptor 5 (Gene/Pseudogene); Chemokine (C-C Motif) Receptor 5; HIV-1 Fusion Coreceptor; CC-CKR-5; ChemR13; CMKBR5; CCR-5; Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene); C-C Motif Chemokine Receptor 5 A159A; Chemokine Recptor CCR5 Delta32;
Function
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Biological Process
Anaphase-promoting complex-dependent catabolic process Source: Reactome
Cell division Source: UniProtKB-KW
Cellular response to fatty acid Source: Ensembl
Cellular response to hypoxia Source: Ensembl
Cellular response to iron(III) ion Source: Ensembl
Cellular response to organic cyclic compound Source: Ensembl
Digestive tract development Source: Ensembl
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
G2/M transition of mitotic cell cycle Source: Reactome
Histone H3-S10 phosphorylation involved in chromosome condensation Source: Ensembl
In utero embryonic development Source: Ensembl
Mitotic cell cycle phase transition Source: GO_Central
Mitotic chromosome condensation Source: Reactome
Mitotic metaphase plate congression Source: BHF-UCL
Mitotic nuclear envelope disassembly Source: Reactome
Mitotic nuclear envelope reassembly Source: Reactome
Mitotic spindle organization Source: BHF-UCL
Negative regulation of gene expression Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Oocyte maturation Source: Ensembl
Positive regulation of attachment of spindle microtubules to kinetochore Source: BHF-UCL
Positive regulation of cardiac muscle cell proliferation Source: Ensembl
Positive regulation of fibroblast proliferation Source: Ensembl
Positive regulation of G2/M transition of mitotic cell cycle Source: CAFA
Positive regulation of histone phosphorylation Source: Ensembl
Positive regulation of mitochondrial ATP synthesis coupled electron transport Source: CAFA
Positive regulation of mitotic cell cycle Source: BHF-UCL
Positive regulation of mRNA 3'-end processing Source: Ensembl
Protein-containing complex assembly Source: Ensembl
Regulation of cell cycle Source: Reactome
Regulation of chromosome condensation Source: Ensembl
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of mitotic cell cycle phase transition Source: Reactome
Regulation of mitotic cell cycle spindle assembly checkpoint Source: BHF-UCL
Regulation of transcription initiation from RNA polymerase II promoter Source: Reactome
Response to DDT Source: Ensembl
Response to drug Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Rpermatogenesis Source: Ensembl
Tissue regeneration Source: Ensembl
Ventricular cardiac muscle cell development Source: Ensembl
Cellular Location
Centrosome; Cytoplasm; Nucleus
PTM
Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.
Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.

Yang, M., Hu, C., Cao, Y., Liang, W., Yang, X., & Xiao, T. (2021). Ursolic Acid Regulates Cell Cycle and Proliferation in Colon Adenocarcinoma by Suppressing Cyclin B1. Frontiers in pharmacology, 11, 2261.

Mamoor, S. (2021). Over-expression of cyclin B1 in human endometrial cancer.

Liu, H., Xu, C., Bao, M., Huang, J., Zou, L., Fan, X., ... & Xia, W. (2021). Cold‐inducible RNA‐binding protein regulates cyclin B1 against spermatogenesis arrest caused by heat stress. Andrology.

Hou, Y., Wang, X., Wang, J., Sun, X., Liu, X., Hu, H., ... & Wu, D. (2021). Cyclin B1 acts as a tumor microenvironment-related cancer promoter and prognostic biomarker in hepatocellular carcinoma. Journal of International Medical Research, 49(5), 03000605211016265.

Ersvær, E., Kildal, W., Vlatkovic, L., Cyll, K., Pradhan, M., Kleppe, A., ... & Danielsen, H. E. (2020). Prognostic value of mitotic checkpoint protein BUB3, cyclin B1, and pituitary tumor-transforming 1 expression in prostate cancer. Modern Pathology, 33(5), 905-915.

Bai, X., Wang, W., Zhao, P., Wen, J., Guo, X., Shen, T., ... & Yang, X. (2020). LncRNA CRNDE acts as an oncogene in cervical cancer through sponging miR-183 to regulate CCNB1 expression. Carcinogenesis, 41(1), 111-121.

Li, J., Tang, J. X., Cheng, J. M., Hu, B., Wang, Y. Q., Aalia, B., ... & Liu, Y. X. (2018). Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I. Journal of Cell Biology, 217(11), 3901-3911.

Sun, J., Guo, Y., Zhang, Q., Bu, S., Li, B., Wang, Q., & Lai, D. (2018). Chronic restraint stress disturbs meiotic resumption through APC/C-mediated cyclin B1 excessive degradation in mouse oocytes. Cell Cycle, 17(13), 1591-1601.

Han, S. J., Martins, J. P. S., Yang, Y., Kang, M. K., Daldello, E. M., & Conti, M. (2017). The translation of cyclin B1 and B2 is differentially regulated during mouse oocyte reentry into the meiotic cell cycle. Scientific reports, 7(1), 1-12.

Zhao, P., Zhang, P., Hu, W., Wang, H., Yu, G., Wang, Z., ... & Zhang, Y. (2017). Upregulation of cyclin B1 plays potential roles in the invasiveness of pituitary adenomas. Journal of Clinical Neuroscience, 43, 267-273.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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