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Hamster Anti-CCR6 Recombinant Antibody (29-2L17) (CBMAB-C0797-LY)

This product is antibody recognizes CCR6. The antibody 29-2L17 immunoassay techniques such as: FC.
See all CCR6 antibodies

Summary

Host Animal
Hamster
Specificity
Mouse
Clone
29-2L17
Antibody Isotype
IgG
Application
FC

Basic Information

Immunogen
N-terminal peptide (aa. 2-38) of mouse CCR6 fused with GST
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-C Motif Chemokine Receptor 6
Introduction
CCR6 (C-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CCR6 include Limited Scleroderma and Diffuse Cutaneous Systemic Sclerosis. Among its related pathways are Defensins and Akt Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity.
An important paralog of this gene is CCR7.
Entrez Gene ID
UniProt ID
Function
Receptor for the C-C type chemokine CCL20 (PubMed:9169459).
Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036).
Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877).
Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636).
Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036).
The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174).
CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity).
Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).
Biological Process
Calcium-mediated signaling Source: UniProtKB
Cell chemotaxis Source: UniProtKB
Cellular defense response Source: ProtInc
Chemotaxis Source: UniProtKB
Dendritic cell chemotaxis Source: BHF-UCL
DN2 thymocyte differentiation Source: UniProtKB
DN3 thymocyte differentiation Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Humoral immune response Source: ProtInc
Immune response Source: GO_Central
Isotype switching to IgA isotypes Source: UniProtKB
Leukocyte migration involved in inflammatory response Source: UniProtKB
Lymphocyte migration Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of dendritic cell chemotaxis Source: GO_Central
Positive regulation of epithelial cell migration Source: Ensembl
Positive regulation of flagellated sperm motility involved in capacitation Source: UniProtKB
Regulation of T cell migration Source: UniProtKB
Signal transduction Source: ProtInc
T cell migration Source: UniProtKB
Thymocyte migration Source: UniProtKB
Cellular Location
Cell membrane; Cell surface
Topology
Extracellular: 1-47
Helical: 48-74
Cytoplasmic: 75-83
Helical: 84-104
Extracellular: 105-119
Helical: 120-141
Cytoplasmic: 142-159
Helical: 160-180
Extracellular: 181-211
Helical: 212-238
Cytoplasmic: 239-254
Helical: 255-279
Extracellular: 280-303
Helical: 304-321
Cytoplasmic: 322-374

Zhang, Y. M., Liu, X. Z., Zhou, X. J., Liu, L. J., Shi, S. F., Hou, P., ... & Zhang, H. (2021). A Functional Variant rs3093023 in CCR6 Is Associated With IgA Nephropathy by Regulating Th17 Cells in a North Han Chinese Population. Frontiers in Immunology, 12, 412.

Wasilko, D. J., Johnson, Z. L., Ammirati, M., Che, Y., Griffor, M. C., Han, S., & Wu, H. (2020). Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20. Nature communications, 11(1), 1-9.

Ansari, M. A., Bakheet, S. A., Al-Ayadhi, L. Y., Khan, M. R., Attia, S. M., & Ahmad, S. F. (2020). CC motif chemokine receptor 6-mediated pro-inflammatory mediator expression is associated with immune dysfunction in children with autism. Research in Autism Spectrum Disorders, 71, 101500.

Kadomoto, S., Izumi, K., & Mizokami, A. (2020). The CCL20-CCR6 axis in cancer progression. International Journal of Molecular Sciences, 21(15), 5186.

Skovdahl, H. K., Damås, J. K., Granlund, A. V. B., Østvik, A. E., Doseth, B., Bruland, T., ... & Sandvik, A. K. (2018). CC motif ligand 20 (CCL20) and CC motif chemokine receptor 6 (CCR6) in human peripheral blood mononuclear cells: dysregulated in ulcerative colitis and a potential role for CCL20 in IL-1β release. International journal of molecular sciences, 19(10), 3257.

Ranasinghe, R., & Eri, R. (2018). Pleiotropic immune functions of chemokine receptor 6 in health and disease. Medicines, 5(3), 69.

Chang, H., Wei, J. W., Tao, Y. L., Ding, P. R., Xia, Y. F., Gao, Y. H., & Xiao, W. W. (2018). CCR6 is a predicting biomarker of radiosensitivity and potential target of radiosensitization in rectal cancer. Cancer research and treatment: official journal of Korean Cancer Association, 50(4), 1203.

Chen, J., Martindale, J. L., Cramer, C., Gorospe, M., Atasoy, U., Drew, P. D., & Yu, S. (2017). The RNA-binding protein HuR contributes to neuroinflammation by promoting CC chemokine receptor 6 (CCR6) expression on Th17 cells. Journal of Biological Chemistry, 292(35), 14532-14543.

Zhang, X. P., Hu, Z. J., Meng, A. H., Duan, G. C., Zhao, Q. T., & Yang, J. (2017). Role of CCL20/CCR6 and the ERK signaling pathway in lung adenocarcinoma. Oncology letters, 14(6), 8183-8189.

Liu, J., Zheng, X., Deng, H., Xu, B., Chen, L., Wang, Q., ... & Jiang, J. (2017). Expression of CCR6 in esophageal squamous cell carcinoma and its effects on epithelial-to-mesenchymal transition. Oncotarget, 8(70), 115244.

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For research use only. Not intended for any clinical use.

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