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Mouse Anti-CCR7 Recombinant Antibody (CBXC-0978) (CBMAB-C1240-CQ)

This product is a mouse antibody that recognizes CCR7. The antibody CBXC-0978 can be used for immunoassay techniques such as: FC.
See all CCR7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0978
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
Human CCR7 transfectants, Met1-Pro378, Accession # AAA58615
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution containing BSA
Preservative
Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-C Motif Chemokine Receptor 7
Introduction
CCR7 (C-C Motif Chemokine Receptor 7) is a Protein Coding gene. Diseases associated with CCR7 include Chronic Actinic Dermatitis and Pars Planitis. Among its related pathways are Akt Signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine (C-C motif) ligand 19 binding. An important paralog of this gene is CCR9.
Entrez Gene ID
1236
UniProt ID
P32248
Alternative Names
C-C Motif Chemokine Receptor 7; Epstein-Barr Virus-Induced G-Protein Coupled Receptor 1; Chemokine (C-C Motif) Receptor 7; MIP-3 Beta Receptor; CC-CKR-7; CMKBR7; CDw197; CCR-7; EBI1; BLR2; Lymphocyte-Specific G Protein-Coupled Peptide Receptor;
Function
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
Biological Process
Activation of GTPase activity Source: BHF-UCL
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Cellular response to cytokine stimulus Source: BHF-UCL
Dendritic cell chemotaxis Source: BHF-UCL
Establishment of T cell polarity Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: BHF-UCL
Homeostasis of number of cells Source: Ensembl
Immune response Source: GO_Central
Inflammatory response Source: BHF-UCL
Lymphocyte migration into lymph node Source: BHF-UCL
Mature conventional dendritic cell differentiation Source: BHF-UCL
Myeloid dendritic cell chemotaxis Source: BHF-UCL
Negative regulation of dendritic cell apoptotic process Source: BHF-UCL
Negative regulation of interleukin-12 production Source: BHF-UCL
Negative thymic T cell selection Source: Ensembl
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of cell adhesion Source: BHF-UCL
Positive regulation of cell-matrix adhesion Source: BHF-UCL
Positive regulation of cell motility Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
Positive regulation of dendritic cell chemotaxis Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of filopodium assembly Source: BHF-UCL
Positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Source: BHF-UCL
Positive regulation of humoral immune response Source: BHF-UCL
Positive regulation of hypersensitivity Source: BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
Positive regulation of immunological synapse formation Source: BHF-UCL
Positive regulation of interleukin-12 production Source: BHF-UCL
Positive regulation of JNK cascade Source: BHF-UCL
Positive regulation of neutrophil chemotaxis Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
Positive regulation of protein kinase activity Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of pseudopodium assembly Source: BHF-UCL
Positive regulation of T cell costimulation Source: BHF-UCL
Positive regulation of T cell receptor signaling pathway Source: Ensembl
Regulation of dendritic cell dendrite assembly Source: BHF-UCL
Regulation of interferon-gamma production Source: BHF-UCL
Regulation of interleukin-1 beta production Source: BHF-UCL
Release of sequestered calcium ion into cytosol Source: BHF-UCL
Response to lipopolysaccharide Source: Ensembl
Response to nitric oxide Source: BHF-UCL
Response to prostaglandin E Source: BHF-UCL
Ruffle organization Source: BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 25-59
Helical: 60-86
Cytoplasmic: 87-95
Helical: 96-116
Extracellular: 117-130
Helical: 131-152
Cytoplasmic: 153-170
Helical: 171-191
Extracellular: 192-219
Helical: 220-247
Cytoplasmic: 248-263
Helical: 264-289
Extracellular: 290-313
Helical: 314-331
Cytoplasmic: 332-378

Nagasawa, S., Tsuchida, K., Shiozawa, M., Hiroshima, Y., Kimura, Y., Hashimoto, I., ... & Oshima, T. (2021). Clinical Significance of Chemokine Receptor CXCR4 and CCR7 mRNA Expression in Patients With Colorectal Cancer. Anticancer Research, 41(9), 4489-4495.

Wen, Y., Rudemiller, N. P., Zhang, J., Lu, X., Ren, J., Privratsky, J. R., ... & Crowley, S. D. (2020). CC Motif Chemokine Receptor 7 Exacerbates Hypertension Through Effects on T Lymphocyte Trafficking. Hypertension, 75(3), 869-876.

Yan, Y., Chen, R., Wang, X., Hu, K., Huang, L., Lu, M., & Hu, Q. (2019). CCL19 and CCR7 expression, signaling pathways, and adjuvant functions in viral infection and prevention. Frontiers in cell and developmental biology, 7, 212.

An, S., Tiruthani, K., Wang, Y., Xu, L., Hu, M., Li, J., ... & Huang, L. (2019). Locally Trapping the C‐C Chemokine Receptor Type 7 by Gene Delivery Nanoparticle Inhibits Lymphatic Metastasis Prior to Tumor Resection. Small, 15(9), 1805182.

Jaeger, K., Bruenle, S., Weinert, T., Guba, W., Muehle, J., Miyazaki, T., ... & Standfuss, J. (2019). Structural basis for allosteric ligand recognition in the human CC chemokine receptor 7. Cell, 178(5), 1222-1230.

Mueller, P. A., Zhu, L., Tavori, H., Huynh, K., Giunzioni, I., Stafford, J. M., ... & Fazio, S. (2018). Deletion of macrophage low-density lipoprotein receptor-related protein 1 (LRP1) accelerates atherosclerosis regression and increases CC chemokine receptor type 7 (CCR7) expression in plaque macrophages. Circulation, 138(17), 1850-1863.

Zhang, J. F., Li, Y., Zhang, A. Z., He, Q. Q., Du, Y. C., & Cao, W. (2018). Expression and pathological significance of CC chemokine receptor 7 and its ligands in the airway of asthmatic rats exposed to cigarette smoke. Journal of thoracic disease, 10(9), 5459.

Wu, J., Li, L., Liu, J., Wang, Y., Wang, Z., Wang, Y., ... & Yang, R. (2018). CC chemokine receptor 7 promotes triple-negative breast cancer growth and metastasis. Acta biochimica et biophysica Sinica, 50(9), 835-842.

Zhong, G., Chen, L., Yin, R., Qu, Y., Bao, Y., Xiao, Q., ... & Tian, H. (2017). Chemokine (C‑C motif) ligand 21/C‑C chemokine receptor type 7 triggers migration and invasion of human lung cancer cells by epithelial‑mesenchymal transition via the extracellular signal‑regulated kinase signaling pathway. Molecular medicine reports, 15(6), 4100-4108.

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For research use only. Not intended for any clinical use.

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