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Mouse Anti-CCR9 Recombinant Antibody (3E3) (CBMAB-C5950-LY)

This product is antibody recognizes CCR9. The antibody 3E3 immunoassay techniques such as: WB, IP, ELISA, IHC-P.
See all CCR9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E3
Antibody Isotype
IgG2b
Application
WB, IP, ELISA, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-C Motif Chemokine Receptor 9
Introduction
CCR9 (C-C Motif Chemokine Receptor 9) is a Protein Coding gene. Diseases associated with CCR9 include Celiac Disease 1 and Cd45 Deficiency. Among its related pathways are Akt Signaling and Allograft rejection. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity.
An important paralog of this gene is CCR7.
Entrez Gene ID
10803
UniProt ID
P51686
Alternative Names
C-C Motif Chemokine Receptor 9; Chemokine (C-C Motif) Receptor 9; CC-CKR-9; GPR-9-6; GPR28; C-C Chemokine Receptor Type 9; G Protein-Coupled Receptor 28;
Function
Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level.
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.
Biological Process
Calcium-mediated signaling Source: GO_Central
CD8-positive, gamma-delta intraepithelial T cell differentiation Source: Ensembl
Cell chemotaxis Source: GO_Central
Cellular defense response Source: ProtInc
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Viral process Source: UniProtKB-KW
Cellular Location
Cell membrane
Topology
Extracellular: 1-48
Helical: 49-74
Cytoplasmic: 75-85
Helical: 86-109
Extracellular: 110-120
Helical: 121-150
Cytoplasmic: 151-159
Helical: 160-185
Extracellular: 186-208
Helical: 209-243
Cytoplasmic: 244-248
Helical: 249-283
Extracellular: 284-290
Helical: 291-321
Cytoplasmic: 322-369

Amiya, T., Nakamoto, N., Irie, J., Taniki, N., Chu, P. S., Koda, Y., ... & Kanai, T. (2021). CC motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice. Diabetologia, 64(3), 603-617.

Morikawa, R., Nakamoto, N., Amiya, T., Chu, P. S., Koda, Y., Teratani, T., ... & Kanai, T. (2021). Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis. Journal of Hepatology, 74(3), 511-521.

Nanamiya, R., Takei, J., Asano, T., Tanaka, T., Sano, M., Nakamura, T., ... & Kato, Y. (2021). Development of Anti-Human CC Chemokine Receptor 9 Monoclonal Antibodies for Flow Cytometry. Monoclonal antibodies in immunodiagnosis and immunotherapy, 40(3), 101-106.

Niu, Y., Tang, D., Fan, L., Gao, W., & Lin, H. (2020). CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner. Experimental and therapeutic medicine, 19(6), 3571-3580.

Atanes, P., Lee, V., Huang, G. C., & Persaud, S. J. (2020). The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes. Metabolism, 113, 154394.

Korbecki, J., Grochans, S., Gutowska, I., Barczak, K., & Baranowska-Bosiacka, I. (2020). CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands. International journal of molecular sciences, 21(20), 7619.

Igaki, K., Komoike, Y., Nakamura, Y., Watanabe, T., Yamasaki, M., Fleming, P., ... & Tsuchimori, N. (2018). MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model. International immunopharmacology, 60, 160-169.

Wang, C., Liu, Z., Xu, Z., Wu, X., Zhang, D., Zhang, Z., & Wei, J. (2018). The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells. Oncology letters, 16(2), 2071-2077.

Hu, Y., Ma, A., Lin, S., Yang, Y., & Hong, G. (2017). Novel peptide screened from a phage display library antagonizes the activity of CC chemokine receptor 9. Oncology letters, 14(6), 6471-6476.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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