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Mouse Anti-CD160 Recombinant Antibody (12K49) (CBMAB-C2680-LY)

This product is antibody recognizes CD160. The antibody 12K49 immunoassay techniques such as: FC.
See all CD160 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
12K49
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
Recombinant corresponding to aa27-159 from human CD160 expressed in CHO cell line
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD160 Molecule
Introduction
CD160 (CD160 Molecule) is a Protein Coding gene. Diseases associated with CD160 include Neurotrophic Keratopathy. Among its related pathways are Innate Immune System and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Gene Ontology (GO) annotations related to this gene include receptor binding and MHC class I receptor activity.
Entrez Gene ID
11126
UniProt ID
O95971
Alternative Names
CD160 Molecule; CD160 Antigen; Natural Killer Cell Receptor BY55; BY55; Natural Killer Cell Receptor, Immunoglobulin Superfamily Member; CD160 Transmembrane Isoform; CD160-Delta Ig; NK28; NK1;
Function
Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed:19109136, PubMed:11978774, PubMed:17307798).
Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372, PubMed:12486241).
In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed:12486241).
On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells (PubMed:9973372).
Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed:25255144).
On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed:16809620).
Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity).
On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050).
In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Angiogenesis Source: UniProtKB-KW
Defense response to Gram-negative bacterium Source: Ensembl
Innate immune response Source: UniProtKB-KW
Mucosal immune response Source: Ensembl
Negative regulation of adaptive immune memory response Source: UniProtKB
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of CD4-positive, alpha-beta T cell costimulation Source: UniProtKB
Negative regulation of T cell receptor signaling pathway Source: UniProtKB
Phosphatidylinositol 3-kinase signaling Source: UniProtKB
Positive regulation of endothelial cell apoptotic process Source: UniProtKB
Positive regulation of interferon-gamma production Source: Ensembl
Positive regulation of natural killer cell cytokine production Source: UniProtKB
Positive regulation of natural killer cell degranulation Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
Positive regulation of natural killer cell mediated immune response to tumor cell Source: Ensembl
Regulation of immune response Source: Reactome
T cell costimulation Source: UniProtKB
Cellular Location
Cell membrane; Secreted. Released from the cell membrane by GPI cleavage.

Del Rio, M. L., Nguyen, T. H., Tesson, L., Heslan, J. M., Gutierrez-Adan, A., Fernandez-Gonzalez, R., ... & Rodriguez-Barbosa, J. I. (2021). The impact of CD160 deficiency on alloreactive CD8 T cell responses and allograft rejection. Translational Research.

Lenhartová, S., Nemčovič, M., Šebová, R., Benko, M., Zajonc, D. M., & Nemčovičová, I. (2021). Molecular Characterization of the Native (Non-Linked) CD160–HVEM Protein Complex Revealed by Initial Crystallographic Analysis. Crystals, 11(7), 820.

Piotrowska, M., Spodzieja, M., Kuncewicz, K., Rodziewicz-Motowidło, S., & Orlikowska, M. (2021). CD160 protein as a new therapeutic target in a battle against autoimmune, infectious and lifestyle diseases. Analysis of the structure, interactions and functions. European Journal of Medicinal Chemistry, 113694.

Di Censo, C., Marotel, M., Mattiola, I., Müller, L., Scarno, G., Pietropaolo, G., ... & Sciumè, G. (2021). Granzyme A and CD160 expression delineates ILC1 with graded functions in the mouse liver. European Journal of Immunology, 51(11), 2568-2575.

Anestakis, D., Petanidis, S., Domvri, K., Tsavlis, D., Zarogoulidis, P., & Katopodi, T. (2020). Carboplatin chemoresistance is associated with CD11b+/Ly6C+ myeloid release and upregulation of TIGIT and LAG3/CD160 exhausted T cells. Molecular immunology, 118, 99-109.

Liu, S., Zhang, W., Liu, K., & Wang, Y. (2020). CD160 expression on CD8+ T cells is associated with active effector responses but limited activation potential in pancreatic cancer. Cancer Immunology, Immunotherapy, 1-9.

Rodriguez-Barbosa, J. I., Schneider, P., Weigert, A., Lee, K. M., Kim, T. J., Perez-Simon, J. A., & Del Rio, M. L. (2019). HVEM, a cosignaling molecular switch, and its interactions with BTLA, CD160 and LIGHT. Cellular & molecular immunology, 16(7), 679-682.

Liu, W., Garrett, S. C., Fedorov, E. V., Ramagopal, U. A., Garforth, S. J., Bonanno, J. B., & Almo, S. C. (2019). Structural basis of CD160: HVEM recognition. Structure, 27(8), 1286-1295.

Kuncewicz, K., Spodzieja, M., Sieradzan, A., Karczyńska, A., Dąbrowska, K., Dadlez, M., ... & Rodziewicz-Motowidło, S. (2019). A structural model of the immune checkpoint CD160–HVEM complex derived from HDX-mass spectrometry and molecular modeling. Oncotarget, 10(4), 536.

Muscate, F., Stetter, N., Schramm, C., Schulze zur Wiesch, J., Bosurgi, L., & Jacobs, T. (2018). HVEM and CD160: regulators of immunopathology during malaria blood-stage. Frontiers in immunology, 9, 2611.

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For research use only. Not intended for any clinical use.

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