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Mouse Anti-CD164 Recombinant Antibody (CBXC-2981) (CBMAB-C1689-CQ)

This product is a mouse antibody that recognizes CD164. The antibody CBXC-2981 can be used for immunoassay techniques such as: FC.
See all CD164 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2981
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD164 molecule, sialomucin
Introduction
CD164 (CD164 Molecule) is a Protein Coding gene. Diseases associated with CD164 include Deafness, Autosomal Dominant 66 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Lysosome. An important paralog of this gene is CD164L2.
Entrez Gene ID
UniProt ID
Alternative Names
CD164 Molecule; Multi-Glycosylated Core Protein 24; CD164 Antigen, Sialomucin; Endolyn; MGC-24v; MGC-24; MUC-24;
Function
Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to the stroma and by negatively regulating CD34+CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).
Biological Process
Cell adhesion Source: MGI
Hemopoiesis Source: UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
Immune response Source: ProtInc
Multicellular organism development Source: ProtInc
Muscle organ development Source: UniProtKB-KW
Negative regulation of cell adhesion Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Lysosome membrane; Endosome membrane; Cell membrane
Isoform 2: Secreted
Involvement in disease
Deafness, autosomal dominant, 66 (DFNA66): A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Topology
Extracellular: 24-162
Helical: 163-183
Cytoplasmic: 184-197
PTM
Highly N- and O-glycosylated; contains sialic acid.
The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.

Watt, S. M., Bühring, H. J., Simmons, P. J., & Zannettino, A. W. (2021). The stem cell revolution: on the role of CD164 as a human stem cell marker. NPJ Regenerative Medicine, 6(1), 1-6.

Mancarella, C., Caldoni, G., Ribolsi, I., Parra, A., Manara, M. C., Mercurio, A. M., ... & Scotlandi, K. (2020). Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis. Frontiers in Oncology, 10, 994.

Zhang, L., Wang, Y., & Su, H. (2020). Long non-coding RNA LINC00152/miR-613/CD164 axis regulates cell proliferation, apoptosis, migration and invasion in glioma via PI3K/AKT pathway. Neoplasma, 67(4), 762-772.

Wang, C. C., Hueng, D. Y., Huang, A. F., Chen, W. L., Huang, S. M., & Chan, J. Y. H. (2019). CD164 regulates proliferation, progression, and invasion of human glioblastoma cells. Oncotarget, 10(21), 2041.

Mancarella, C., Manara, M. C., Mercurio, A. M., & Scotlandi, K. (2019). Insulin-like growth factor 2 (IGF-2) mRNA binding protein 3-mediated regulation of CD164-CXCR4 axis impacts aggressiveness of Ewing sarcoma.

Tu, M., & Zheng, W. (2018). CD164 induced the apoptosis of U87 cell by down-regulating PTEN/PI3K/AKT signal pathway in vitro.

Chen, W. L., Huang, A. F., Huang, S. M., Ho, C. L., Chang, Y. L., & Chan, J. Y. H. (2017). CD164 promotes lung tumor-initiating cells with stem cell activity and determines tumor growth and drug resistance via Akt/mTOR signaling. Oncotarget, 8(33), 54115.

Tu, M., Cai, L., Zheng, W., Su, Z., Chen, Y., & Qi, S. (2017). CD164 regulates proliferation and apoptosis by targeting PTEN in human glioma. Molecular medicine reports, 15(4), 1713-1721.

Benoit, B. M., Jariwala, N., O’Connor, G., Oetjen, L. K., Whelan, T. M., Werth, A., ... & Wysocka, M. (2017). CD164 identifies CD4+ T cells highly expressing genes associated with malignancy in Sézary syndrome: the Sézary signature genes, FCRL3, Tox, and miR-214. Archives of dermatological research, 309(1), 11-19.

Chen, J. H., Chen, W. L., Chan, J. Y. H., Chen, Y. W., Peng, Y. J., Cheng, M. F., & Lin, C. S. (2017). Overexpression of CD164 in oral cavity squamous cell carcinoma predicts a favourable prognosis. Oncology letters, 14(5), 6103-6108.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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