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Mouse Anti-CD1A Recombinant Antibody (5F1) (CBMAB-C7530-LY)

This product is antibody recognizes CD1A. The antibody 5F1 immunoassay techniques such as: FC, IF, IHC.
See all CD1A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5F1
Antibody Isotype
IgG1, κ
Application
FC, IF, IHC

Basic Information

Immunogen
CD1a
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD1a Molecule
Introduction
CD1A (CD1a Molecule) is a Protein Coding gene. Diseases associated with CD1A include Langerhans Cell Histiocytosis and Histiocytosis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include beta-2-microglobulin binding and endogenous lipid antigen binding.
An important paralog of this gene is CD1B.
Entrez Gene ID
UniProt ID
Alternative Names
CD1a Molecule; T-Cell Surface Antigen T6/Leu-6; CD1A Antigen, A Polypeptide; HTa1 Thymocyte Antigen; CD1a Antigen; Epidermal Dendritic Cell Marker CD1a; Differentiation Antigen CD1-Alpha-3; T-Cell Surface Glycoprotein CD1a;
Function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Immune response Source: UniProtKB
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
Cellular Location
Endosome membrane; Cell membrane; Membrane raft. Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838).
Topology
Extracellular: 17-300
Helical: 301-321
Cytoplasmic: 322-327

de Jong, A., & Ogg, G. (2021). CD1a function in human skin disease. Molecular Immunology, 130, 14-19.

Gapin, L. (2021). CD1a autoreactivity: When size does matter.

Yoo, H. J., Kim, N. Y., & Kim, J. H. (2021). Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System. Molecules and Cells, 44(5), 310.

Cotton, R. N., Wegrecki, M., Cheng, T. Y., Chen, Y. L., Veerapen, N., Le Nours, J., ... & Moody, D. B. (2021). CD1a selectively captures endogenous cellular lipids that broadly block T cell response. Journal of Experimental Medicine, 218(7), e20202699.

Cotton, R. N., Cheng, T. Y., Wegrecki, M., Le Nours, J., Orgill, D. P., Pomahac, B., ... & Moody, D. B. (2021). Human skin is colonized by T cells that recognize CD1a independently of lipid. The Journal of clinical investigation, 131(1).

Nicolai, S., Wegrecki, M., Cheng, T. Y., Bourgeois, E. A., Cotton, R. N., Mayfield, J. A., ... & de Jong, A. (2020). Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products. Science immunology, 5(43).

Sánchez-Martínez, D., Baroni, M. L., Gutierrez-Agüera, F., Roca-Ho, H., Blanch-Lombarte, O., González-García, S., ... & Menéndez, P. (2019). Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia. Blood, The Journal of the American Society of Hematology, 133(21), 2291-2304.

Taheri, M., Danesh, H., Bizhani, F., Bahari, G., Naderi, M., & Hashemi, M. (2019). Association between genetic variants in CD1A and CD1D genes and pulmonary tuberculosis in an Iranian population. Biomedical reports, 10(4), 259-265.

Rahman, M. I., Jahan, I., Khalid, M. M., Jahan, I., Ahammad, R. U., Nahar, S., & Islam, Z. (2018). CD1A and CD1E gene polymorphisms are not associated with susceptibility to Guillain-Barré syndrome in the Bangladeshi population. Journal of neuroimmunology, 314, 8-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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