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Mouse Anti-CD209 Recombinant Antibody (109H12.03) (CBMAB-D0043-YC)

Provided herein is a Mouse monoclonal antibody, which binds to CD209 Molecule (CD209). The antibody can be used for immunoassay techniques, such as FC, IHC-Fr, ICC, IF, IHC-P.
See all CD209 antibodies
Published Data
Fig.1 The cell suspension was incubated with anti-CD209 mAb or its isotype control together with anti-CD14 mAb and analyzed by flow cytometry.
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Fig.2 Human CD209⁺ dMψ stained for IL-10.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
109H12.03
Antibody Isotype
IgG2a
Application
FC, IHC-Fr, ICC, IF, IHC-P

Basic Information

Immunogen
Human CD209-transfected HeLa cells
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD209 Molecule
Introduction
CD209 (CD209 Molecule) is a protein coding gene. Diseases associated with CD209 include Dengue Virus and Human Immunodeficiency Virus Type 1. Among its related pathways are CLEC7A (Dectin-1) signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers.
Entrez Gene ID
30835
UniProt ID
Q9NNX6
Alternative Names
CD209 Molecule; CD209 Antigen; Dendritic Cell-Specific ICAM-3-Grabbing Non-Integrin 1; C-Type Lectin Domain Family 4 Member L; DC-SIGN1; DC-SIGN;
Function
Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.
On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
(Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2.
(Microbial infection) Acts as an attachment receptor for Ebolavirus.
(Microbial infection) Acts as an attachment receptor for Cytomegalovirus.
(Microbial infection) Acts as an attachment receptor for HCV.
(Microbial infection) Acts as an attachment receptor for Dengue virus.
(Microbial infection) Acts as an attachment receptor for Measles virus.
(Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1.
(Microbial infection) Acts as an attachment receptor for Influenzavirus A.
(Microbial infection) Acts as an attachment receptor for SARS-CoV.
(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.
(Microbial infection) Acts as an attachment receptor for Lassa virus (PubMed:23966408). Acts as an attachment receptor for Marburg virusn.
(Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus.
(Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus.
(Microbial infection) Acts as an attachment receptor for West-nile virus.
(Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA (PubMed:16379498).
Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule (PubMed:16092920, PubMed:21203928).
Biological Process
Adaptive immune response Source: Reactome
Antigen processing and presentation Source: UniProtKB
B cell adhesion Source: UniProtKB
Cell-cell recognition Source: UniProtKB
Endocytosis Source: UniProtKB-KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Intracellular signal transduction Source: UniProtKB
Intracellular transport of virus Source: UniProtKB
Leukocyte cell-cell adhesion Source: UniProtKB
Modulation by virus of host process Source: UniProtKB
Peptide antigen transport Source: UniProtKB
Positive regulation of T cell proliferation Source: UniProtKB
Positive regulation of viral life cycle Source: FlyBase
Regulation of T cell proliferation Source: MGI
Stimulatory C-type lectin receptor signaling pathway Source: Reactome
Viral entry into host cell Source: FlyBase
Viral genome replication Source: UniProtKB
Virion attachment to host cell Source: UniProtKB
Cellular Location
Isoform 1&2&3&4&5: Cell membrane
Isoform 6&7&8&9&10&11&12: Secreted
Topology
Cytoplasmic: 1-37
Helical: 38-58
Extracellular: 59-404

Rahimi, N. (2021). C-type lectin CD209L/L-SIGN and CD209/DC-SIGN: cell adhesion molecules turned to pathogen recognition receptors. Biology, 10(1), 1.

Kakar, M. U., Matloob, M., Dai, R., Deng, Y., Ullah, K., Kakar, I. U., ... & Mehboob, M. Z. (2021). In silico screening and identification of deleterious missense SNPs along with their effects on CD-209 gene: An insight to CD-209 related-diseases. Plos one, 16(2), e0247249.

Amraei, R., Yin, W., Napoleon, M. A., Suder, E. L., Berrigan, J., Zhao, Q., ... & Rahimi, N. (2021). CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2. ACS Central Science, 7(7), 1156-1165.

Xue, Y., Li, Q., Park, C. G., Klena, J. D., Anisimov, A. P., Sun, Z., ... & Chen, T. (2021). Proteus mirabilis Targets Atherosclerosis Plaques in Human Coronary Arteries via DC-SIGN (CD209). Frontiers in Immunology, 3351.

Njiri, O. A., Zhang, X., Zhang, Y., Wu, B., Jiang, L., Li, Q., ... & Chen, T. (2020). CD209 C-Type lectins promote host invasion, dissemination, and infection of toxoplasma gondii. Frontiers in immunology, 11, 656.

Deykin, A. V., Kubekina, M. V., Silaeva, Y. Y., Krivonogova, A. S., & Isaeva, A. G. (2020). Using CRISPR/Cas9 for generation the cd209 knockout is a way to get cattle breeds resistant to the bovine leukemia virus (BLV). In E3S Web of Conferences (Vol. 176, p. 01007). EDP Sciences.

He, Y. X., Ye, C. L., Zhang, P., Li, Q., Park, C. G., Yang, K., ... & Chen, T. (2019). Yersinia pseudotuberculosis exploits CD209 receptors for promoting host dissemination and infection. Infection and immunity, 87(1), e00654-18.

Pabalan, N., Chaisri, S., Tabunhan, S., Phumyen, A., Jarjanazi, H., & Steiner, T. S. (2018). Associations of DC-SIGN (CD209) promoter-336G/A polymorphism (rs4804803) with dengue infection: A systematic review and meta-analysis. Acta tropica, 177, 186-193.

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For research use only. Not intended for any clinical use.

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