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Rat Anti-CD24 Recombinant Antibody (5K251) (CBMAB-C7792-LY)

This product is antibody recognizes CD24. The antibody 5K251 immunoassay techniques such as: FC, IP.
See all CD24 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
5K251
Antibody Isotype
IgGc, κ
Application
FC, IP

Basic Information

Specificity
Mouse
Antibody Isotype
IgGc, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD24 Molecule
Introduction
CD24 (CD24 Molecule) is a Protein Coding gene. Diseases associated with CD24 include Multiple Sclerosis. Among its related pathways are L1CAM interactions and Developmental Biology. Gene Ontology (GO) annotations related to this gene include protein kinase binding and carbohydrate binding.
Entrez Gene ID
12484
UniProt ID
P24807
Function
May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396).
In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).
Biological Process
B cell receptor transport into membrane raft Source: UniProtKB
Cell activation Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Cell migration Source: UniProtKB
Chemokine receptor transport out of membrane raft Source: UniProtKB
Cholesterol homeostasis Source: UniProtKB
Glomerular parietal epithelial cell differentiation Source: UniProtKB
Glomerular visceral epithelial cell differentiation Source: UniProtKB
Immune response-regulating cell surface receptor signaling pathway Source: UniProtKB
Intrinsic apoptotic signaling pathway Source: UniProtKB
Negative regulation of transforming growth factor beta3 production Source: UniProtKB
Positive regulation of activated T cell proliferation Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of MAP kinase activity Source: UniProtKB
Positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
Regulation of cytokine-mediated signaling pathway Source: UniProtKB
Regulation of epithelial cell differentiation Source: UniProtKB
Regulation of MAPK cascade Source: UniProtKB
Regulation of phosphorylation Source: UniProtKB
Respiratory burst Source: UniProtKB
Response to estrogen Source: UniProtKB
Response to hypoxia Source: UniProtKB
Response to molecule of bacterial origin Source: UniProtKB
T cell costimulation Source: UniProtKB
Wnt signaling pathway Source: UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Multiple sclerosis (MS): A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
PTM
Extensively O-glycosylated.

Altevogt, P., Sammar, M., Hüser, L., & Kristiansen, G. (2021). Novel insights into the function of CD24: A driving force in cancer. International Journal of Cancer, 148(3), 546-559.

Chantziou, A., Theodorakis, K., Polioudaki, H., de Bree, E., Kampa, M., Mavroudis, D., ... & Theodoropoulos, P. A. (2021). Glycosylation Modulates Plasma Membrane Trafficking of CD24 in Breast Cancer Cells. International journal of molecular sciences, 22(15), 8165.

Wu, H., Liu, J., Wang, Z., Yuan, W., & Chen, L. (2021). Prospects of antibodies targeting CD47 or CD24 in the treatment of glioblastoma. CNS Neuroscience & Therapeutics, 27(10), 1105-1117.

Yin, S. S., & Gao, F. H. (2020). Molecular mechanism of tumor cell immune escape mediated by CD24/Siglec-10. Frontiers in Immunology, 11, 1324.

Tarhriz, V., Bandehpour, M., Dastmalchi, S., Ouladsahebmadarek, E., Zarredar, H., & Eyvazi, S. (2019). Overview of CD24 as a new molecular marker in ovarian cancer. Journal of cellular physiology, 234(3), 2134-2142.

Han, Y., Sun, F., Zhang, X., Wang, T., Jiang, J., Cai, J., ... & Zhang, J. (2019). CD24 targeting bi-specific antibody that simultaneously stimulates NKG2D enhances the efficacy of cancer immunotherapy. Journal of cancer research and clinical oncology, 145(5), 1179-1190.

Ooki, A., VandenBussche, C. J., Kates, M., Hahn, N. M., Matoso, A., McConkey, D. J., ... & Hoque, M. O. (2018). CD24 regulates cancer stem cell (CSC)-like traits and a panel of CSC-related molecules serves as a non-invasive urinary biomarker for the detection of bladder cancer. British journal of cancer, 119(8), 961-970.

Rabinovich, I., Sebastião, A. P. M., Lima, R. S., de Andrade Urban, C., Schunemann Jr, E., Anselmi, K. F., ... & Moreno-Amaral, A. N. (2018). Cancer stem cell markers ALDH1 and CD44+/CD24–phenotype and their prognosis impact in invasive ductal carcinoma. European journal of histochemistry: EJH, 62(3).

Zeng, C., Chen, T., Zhang, Y., & Chen, Q. (2017). Hedgehog signaling pathway regulates ovarian cancer invasion and migration via adhesion molecule CD24. Journal of Cancer, 8(5), 786.

Alaterre, E., Raimbault, S., Goldschmidt, H., Bouhya, S., Requirand, G., Robert, N., ... & Moreaux, J. (2017). CD24, CD27, CD36 and CD302 gene expression for outcome prediction in patients with multiple myeloma. Oncotarget, 8(58), 98931.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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