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Mouse Anti-CD248 Antibody (4B2) (CBMAB-0025-YC)

Provided herein are mouse monoclonal antibodies against Human CD248. The antibody clone 4B2 can be used for immunoassay techniques, such as WB.
See all CD248 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4B2
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD248 Molecule
Introduction
CD248 is a protein that in humans is encoded by the CD248 gene. It is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion processes but also in host defence. This family comprise two other members, CD93 and thrombomodulin.
Entrez Gene ID
UniProt ID
Alternative Names
CD248; CD248 molecule, endosialin; TEM1; CD164L1; endosialin; 2610111G01Rik; CD164 sialomucin-like 1; CD248 antigen, endosialin; tumor endothelial marker 1
Function
May play a role in tumor angiogenesis.
Biological Process
Anatomical structure regression Source: Ensembl
Cell migration Source: GO_Central
Lymph node development Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of endothelial cell apoptotic process Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 18-687
Helical: 688-708
Cytoplasmic: 709-757
PTM
O-glycosylated with sialylated oligosaccharides.
May be N-glycosylated.

Zhang, K., Xu, C., Liu, S., Jiang, Y., Zhao, X., Ma, S., ... & Qin, W. (2021). The Diagnostic and Immunotherapeutic Value of CD248 in Renal Cell Carcinoma. Frontiers in oncology, 11, 510.

Armitage, E. G., Barnes, A., Patrick, K., Bechar, J., Harrison, M. J., Lavery, G. G., ... & Naylor, A. J. (2021). Metabolic consequences for mice lacking Endosialin: LC–MS/MS-based metabolic phenotyping of serum from C56Bl/6J Control and CD248 knock‐out mice. Metabolomics, 17(2), 1-11.

Matsushima, S., Aoshima, Y., Akamatsu, T., Enomoto, Y., Meguro, S., Kosugi, I., ... & Iwashita, T. (2020). CD248 and integrin alpha-8 are candidate markers for differentiating lung fibroblast subtypes. BMC pulmonary medicine, 20(1), 1-15.

Park, G. B., Jeong, J. Y., & Kim, D. (2020). Modified TLR‐mediated downregulation of miR‐125b‐5p enhances CD248 (endosialin)‐induced metastasis and drug resistance in colorectal cancer cells. Molecular carcinogenesis, 59(2), 154-167.

Di Benedetto, P., Ruscitti, P., Liakouli, V., Del Galdo, F., Giacomelli, R., & Cipriani, P. (2019). Linking myofibroblast generation and microvascular alteration: the role of CD248 from pathogenesis to therapeutic target. Molecular medicine reports, 20(2), 1488-1498.

Teicher, B. A. (2019). CD248: A therapeutic target in cancer and fibrotic diseases. Oncotarget, 10(9), 993.

Petrus, P., Fernandez, T. L., Kwon, M. M., Huang, J. L., Lei, V., Safikhan, N. S., ... & Conway, E. M. (2019). Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation. EBioMedicine, 44, 489-501.

Di Benedetto, P., Liakouli, V., Ruscitti, P., Berardicurti, O., Carubbi, F., Panzera, N., ... & Giacomelli, R. (2018). Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: a new potential target for antifibrotic therapy. Arthritis research & therapy, 20(1), 1-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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