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Rabbit Anti-CD276 Recombinant Antibody (SP206) (CBMAB-C10156-LY)

The product is antibody recognizes CD276. The antibody SP206 immunoassay techniques such as: WB, FC.
See all CD276 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
SP206
Antibody Isotype
IgG
Application
WB, FC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD276 Molecule
Introduction
CD276 (CD276 Molecule) is a Protein Coding gene. Diseases associated with CD276 include Neuroblastoma and Acute Cervicitis. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include receptor binding. An important paralog of this gene is LOC102723996.
Entrez Gene ID
Human80381
Mouse102657
Rat315716
UniProt ID
HumanQ5ZPR3
MouseQ8VE98
RatQ7TPB4
Function
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Biological Process
Positive regulation of interferon-gamma production Source: HGNC-UCL
Positive regulation of T cell proliferation Source: HGNC-UCL
Regulation of cytokine production Source: GO_Central
Regulation of immune response Source: HGNC-UCL
T cell activation Source: UniProtKB
T cell receptor signaling pathway Source: GO_Central
Cellular Location
Membrane
Topology
Extracellular: 29-466
Helical: 467-487
Cytoplasmic: 488-534

Fu, M., Zhang, J., Li, W., He, S., Zhang, J., Tennant, D., ... & Mao, Y. (2021). Gene Clusters Based on OLIG2 and CD276 Could Distinguish Molecular Profiling in Glioblastoma.

Wang, M. Y., Qi, B., Wang, F., Lin, Z. R., Li, M. Y., Yin, W. J., ... & Chen, D. P. (2021). PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma. Oncogenesis, 10(1), 1-14.

Liu, X., Zhelev, D., Adams, C., Chen, C., Mellors, J. W., & Dimitrov, D. S. (2021). Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody. Translational oncology, 14(12), 101232.

Kanchan, R. K., Perumal, N., Atri, P., Chirravuri Venkata, R., Thapa, I., Klinkebiel, D. L., ... & Mahapatra, S. (2020). MiR‐1253 exerts tumor‐suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7‐H3). Brain Pathology, 30(4), 732-745.

Li, R., Zatloukalova, P., Muller, P., Gil-Mir, M., Kote, S., Wilkinson, S., ... & Vojtesek, B. (2020). The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276. Cellular & molecular biology letters, 25(1), 1-21.

Cheng, R., Wang, B., Cai, X. R., Chen, Z. S., Du, Q., Zhou, L. Y., ... & Chen, Y. L. (2020). CD276 promotes vasculogenic mimicry formation in hepatocellular carcinoma via the PI3K/AKT/MMPs pathway. OncoTargets and therapy, 13, 11485.

Yu, X., Wei, B., Su, R., Yao, J., Feng, X., Jiang, G., ... & Zhou, L. (2019). A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD 276. Molecular genetics & genomic medicine, 7(6), e689.

Son, Y., Kwon, S. M., & Cho, J. Y. (2019). CD276 (B7‐H3) Maintains Proliferation and Regulates Differentiation in Angiogenic Function in Late Endothelial Progenitor Cells. Stem Cells, 37(3), 382-394.

Bao, R., Wang, Y., Lai, J., Zhu, H., Zhao, Y., Li, S., ... & Liu, Z. (2018). Enhancing anti-PD-1/PD-L1 immune checkpoint inhibitory cancer therapy by CD276-targeted photodynamic ablation of tumor cells and tumor vasculature. Molecular pharmaceutics, 16(1), 339-348.

Hwang, J. Y., Jeong, J. M., Kwon, M. G., Seo, J. S., Hwang, S. D., Son, M. H., ... & Park, C. I. (2018). Olive flounder CD276 (B7-H3) a coinhibitory molecule for T cells: Responses during viral hemorrhagic septicemia virus (VHSV) stimulation. Fish & shellfish immunology, 73, 228-233.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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