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Rat Anti-CD300LF Recombinant Antibody (305835) (CBMAB-C0933-LY)

This product is antibody recognizes CD300LF. The antibody 305835 immunoassay techniques such as: WB, FC, CyTOF.
See all CD300LF antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
305835
Antibody Isotype
IgG1
Application
WB, FC, CyTOF

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD300 Molecule Like Family Member F
Introduction
CD300LF (CD300 Molecule Like Family Member F) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

An important paralog of this gene is CD300LD.
Entrez Gene ID
246746
UniProt ID
Q6SJQ7
Function
Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731).
Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity).
Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150).
May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity).
Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923).
Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).
Biological Process
Immune system process Source: UniProtKB-KW
Interleukin-13-mediated signaling pathway Source: UniProtKB
Negative regulation of apoptotic cell clearance Source: UniProtKB
Negative regulation of mast cell activation Source: UniProtKB
Negative regulation of MyD88-dependent toll-like receptor signaling pathway Source: UniProtKB
Positive regulation of apoptotic cell clearance Source: UniProtKB
Positive regulation of interleukin-4-mediated signaling pathway Source: UniProtKB
Regulation of immune response Source: Reactome
TRIF-dependent toll-like receptor signaling pathway Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 20-156
Helical: 157-177
Cytoplasmic: 178-290
PTM
Phosphorylated on tyrosine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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