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Mouse Anti-CD37 Recombinant Antibody (A048) (CBMAB-AP10659LY)

The product is antibody recognizes CD37. The antibody A048 immunoassay techniques such as: FC, IF, IHC.
See all CD37 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A048
Antibody Isotype
IgG2b
Application
FC, IF, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD37 Molecule
Introduction
CD37 (CD37 Molecule) is a Protein Coding gene. Among its related pathways are Hematopoietic cell lineage. An important paralog of this gene is CD82.
Entrez Gene ID
UniProt ID
Alternative Names
CD37 Molecule; Tetraspanin-26; CD37 Antigen; Tspan-26; TSPAN26; Cell Differentiation Antigen 37; Leukocyte Surface Antigen CD37; Leukocyte Antigen CD37; GP52-40;
Function
AGEL0259
Cellular Location
Membrane
Topology
Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-59
Helical: 60-74
Cytoplasmic: 75-85
Helical: 86-111
Extracellular: 112-241
Helical: 242-266
Cytoplasmic: 267-281

Okuno, S., Adachi, Y., Terakura, S., Julamanee, J., Sakai, T., Umemura, K., ... & Kiyoi, H. (2021). Spacer Length Modification Facilitates Discrimination between Normal and Neoplastic Cells and Provides Clinically Relevant CD37 CAR T Cells. The Journal of Immunology.

van der Horst, H. J., Oostindie, S. C., Cillessen, S. A., Gelderloos, A. T., Overdijk, M. B., Nijhof, I. S., ... & Mutis, T. (2021). Potent preclinical efficacy of DuoHexaBody-CD37 in B-cell malignancies. Hemasphere, 5(1).

Yan, X., Zhou, Q., Zhu, H., Liu, W., Xu, H., Yin, W., ... & Ren, C. (2021). The clinical features, prognostic significance, and immune heterogeneity of CD37 in diffuse gliomas. Iscience, 24(11), 103249.

Oostindie, S. C., van der Horst, H. J., Kil, L. P., Strumane, K., Overdijk, M. B., van den Brink, E. N., ... & Breij, E. C. (2020). DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies. Blood cancer journal, 10(3), 1-13.

Bobrowicz, M., Kubacz, M., Slusarczyk, A., & Winiarska, M. (2020). CD37 in B cell derived tumors—more than just a docking point for monoclonal antibodies. International Journal of Molecular Sciences, 21(24), 9531.

Zhang, Q., Han, Q., Zi, J., Song, C., & Ge, Z. (2020). CD37 high expression as a potential biomarker and association with poor outcome in acute myeloid leukemia. Bioscience reports, 40(5), BSR20200008.

Malenge, M. M. (2020). Combination of anti-CD37 radioimmunotherapy with anti-CD20 immunotherapy and small molecule inhibitors to improve therapy of non-Hodgkin lymphoma.

Oostindie, S. C., Van Der Horst, H. J., Lindorfer, M. A., Cook, E. M., Tupitza, J. C., Zent, C. S., ... & Taylor, R. P. (2019). CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering. haematologica, 104(9), 1841.

Payandeh, Z., Noori, E., Khalesi, B., Mard-Soltani, M., Abdolalizadeh, J., & Khalili, S. (2018). Anti-CD37 targeted immunotherapy of B-Cell malignancies. Biotechnology letters, 40(11), 1459-1466.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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