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Mouse Anti-CD5 Recombinant Antibody (CBYY-C1486) (CBMAB-C2924-YY)

This product is mouse antibody that recognizes CD5. The antibody CBYY-C1486 can be used for immunoassay techniques such as: ELISA, ICC
See all CD5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C1486
Antibody Isotype
IgG1
Application
ELISA, ICC

Basic Information

Immunogen
Human PBL
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1 mg/mL
Preservative
PBS, pH 7.2
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD5 Molecule
Entrez Gene ID
UniProt ID
Alternative Names
CD59 Molecule (CD59 Blood Group); CD59 Antigen P18-20 (Antigen Identified By Monoclonal Antibodies 16.3A5, EJ16, EJ30, EL32 And G344); CD59 Molecule, Complement Regulatory Protein; Membrane Attack Complex Inhibition Factor; Membrane Inhibitor Of Reactive Lysis; 20 KDa Homologous Restriction Factor; MEM43 Antigen; 1F5 Antigen; Protectin; HRF-20; MAC-IP; MIC11; MSK21; HRF20; MACIF; MIN1; MIN2; MIN3; MIRL; Surface Anitgen Recognized By Monoclonal Antibody 16.3A5;
Function
May act as a receptor in regulating T-cell proliferation.
Biological Process
Apoptotic signaling pathway Source: Ensembl
Cell recognition Source: UniProtKB
T cell costimulation Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 25-372
Helical: 373-402
Cytoplasmic: 403-495
PTM
Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.

Velasco-de-Andrés, M., Català, C., Casadó-Llombart, S., Simões, I., Zaragoza, O., Carreras, E., & Lozano, F. (2021). The lymphocyte scavenger receptor CD5 plays a nonredundant role in fungal infection. Cellular & molecular immunology, 18(2), 498-500.

Dai, Z., Mu, W., Zhao, Y., Jia, X., Liu, J., Wei, Q., ... & Zhou, J. (2021). The rational development of CD5-targeting biepitopic CARs with fully human heavy-chain-only antigen recognition domains. Molecular Therapy, 29(9), 2707-2722.

Matson, C. A., Choi, S., Livak, F., Zhao, B., Mitra, A., Love, P. E., & Singh, N. J. (2020). CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation. Proceedings of the National Academy of Sciences, 117(25), 14342-14353.

Velasco-de Andrés, M., Casadó-Llombart, S., Català, C., Leyton-Pereira, A., Lozano, F., & Aranda, F. (2020). Soluble CD5 and CD6: Lymphocytic Class I Scavenger Receptors as Immunotherapeutic Agents. Cells, 9(12), 2589.

Blaize, G., Daniels-Treffandier, H., Aloulou, M., Rouquié, N., Yang, C., Marcellin, M., ... & Lesourne, R. (2020). CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens. Proceedings of the National Academy of Sciences, 117(23), 12969-12979.

Alotaibi, F., Rytelewski, M., Figueredo, R., Zareardalan, R., Zhang, M., Ferguson, P. J., ... & Koropatnick, J. (2020). CD5 blockade enhances ex vivo CD8+ T cell activation and tumour cell cytotoxicity. European journal of immunology, 50(5), 695-704.

Burgueño‐Bucio, E., Mier‐Aguilar, C. A., & Soldevila, G. (2019). The multiple faces of CD5. Journal of leukocyte biology, 105(5), 891-904.

Zhao, P., Li, L., Zhou, S., Qiu, L., Qian, Z., Liu, X., ... & Zhang, H. (2019). CD5 expression correlates with inferior survival and enhances the negative effect of p53 overexpression in diffuse large B‐cell lymphoma. Hematological oncology, 37(4), 360-367.

Voisinne, G., Gonzalez de Peredo, A., & Roncagalli, R. (2018). CD5, an undercover regulator of TCR signaling. Frontiers in immunology, 9, 2900.

Abós, B., Bird, S., Granja, A. G., Morel, E., Bayona, J. A. M., Barreda, D. R., & Tafalla, C. (2018). Identification of the first teleost CD5 molecule: additional evidence on phenotypical and functional similarities between fish IgM+ B cells and mammalian B1 cells. The Journal of Immunology, 201(2), 465-480.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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