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Mouse Anti-CD58 Recombinant Antibody (VC21) (CBMAB-C10508-LY)

The product is antibody recognizes CD58. The antibody VC21 immunoassay techniques such as: FC.
See all CD58 antibodies

Summary

Host Animal
Mouse
Specificity
Rabbit
Clone
VC21
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Rabbit
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD58 Molecule
Introduction
CD58 (CD58 Molecule) is a Protein Coding gene. Diseases associated with CD58 include Whipple Disease and Oral Lichen Planus. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor binding.
Function
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
Biological Process
Cell-cell adhesion Source: UniProtKB
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Heterotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Neutrophil degranulation Source: Reactome
Positive regulation of interleukin-8 production Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 29-215
Helical: 216-238
Cytoplasmic: 239-250

Zhang, Y., Liu, Q., Yang, S., & Liao, Q. (2021). CD58 Immunobiology at a Glance. Frontiers in Immunology, 12, 2212.

Zhang, Y., Liu, Q., Liu, J., & Liao, Q. (2021). Upregulated CD58 is associated with clinicopathological characteristics and poor prognosis of patients with pancreatic ductal adenocarcinoma. Cancer Cell International, 21(1), 1-15.

Tripathi, N., Leherte, L., Vercauteren, D. P., & Laurent, A. D. (2021). Structure-based identification of inhibitors disrupting the CD2–CD58 interactions. Journal of computer-aided molecular design, 35(3), 337-353.

Parajuli, P., Sable, R., Shrestha, L., Dahal, A., Gauthier, T., Taneja, V., & Jois, S. (2021). Modulation of co‐stimulatory signal from CD2–CD58 proteins by a grafted peptide. Chemical Biology & Drug Design, 97(3), 607-627.

Otsuka, Y., Nishikori, M., Arima, H., Izumi, K., Kitawaki, T., Hishizawa, M., & Takaori-Kondo, A. (2020). EZH2 inhibitors restore epigenetically silenced CD58 expression in B-cell lymphomas. Molecular immunology, 119, 35-45.

Yamamoto, M., Watanabe, M., Inoue, N., Watanabe, A., Ozaki, H., Ohsaki, M., ... & Iwatani, Y. (2020). Association of CD58 polymorphisms and its protein expression with the development and prognosis of autoimmune thyroid diseases. Immunological investigations, 49(1-2), 106-119.

Veldman, J., Visser, L., Huberts-Kregel, M., Muller, N., Hepkema, B., Van den Berg, A., & Diepstra, A. (2020). Rosetting T cells in Hodgkin lymphoma are activated by immunological synapse components HLA class II and CD58. Blood, 136(21), 2437-2441.

Leherte, L., Petit, A., Jacquemin, D., Vercauteren, D. P., & Laurent, A. D. (2018). Investigating cyclic peptides inhibiting CD2–CD58 interactions through molecular dynamics and molecular docking methods. Journal of computer-aided molecular design, 32(11), 1295-1313.

Lu, Y. J., Qiu, L. L., & Wang, L. L. (2017). Research Progress on Relationship between CD58 Molecule and ALL and Lymphoma-Review. Zhongguo shi yan xue ye xue za zhi, 25(2), 592-595.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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