Sign in or Register   Sign in or Register
  |  

Rat Anti-CD6 Recombinant Antibody (CBFYC-1381) (CBMAB-C1439-FY)

This product is rat antibody that recognizes CD6. The antibody CBFYC-1381 can be used for immunoassay techniques such as: WB.
See all CD6 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYC-1381
Antibody Isotype
IgG2
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD6 Molecule
Introduction
CD6 (CD6 Molecule) is a Protein Coding gene. Diseases associated with CD6 include Bronchus Cancer and Inflammatory Bowel Disease 16. Among its related pathways are Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is LOXL4.
Entrez Gene ID
UniProt ID
Alternative Names
T-cell differentiation antigen CD6
Function
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089).
Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089).
Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752).
Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806).
Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777).
LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777).
Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).
Biological Process
Acute inflammatory response to antigenic stimulus Source: UniProtKB
Adaptive immune response Source: UniProtKB-KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Immunological synapse formation Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Lipopolysaccharide-mediated signaling pathway Source: UniProtKB
Positive regulation of cytokine production involved in inflammatory response Source: UniProtKB
Positive regulation of T cell proliferation Source: UniProtKB
Response to lipopolysaccharide Source: UniProtKB
Cellular Location
Cell membrane. Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938).
Soluble CD6: Secreted. The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain.
Topology
Extracellular: 18-402
Helical: 403-423
Cytoplasmic: 424-668
PTM
After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.
Glycosylated.

Mori, D., Grégoire, C., Voisinne, G., Celis-Gutierrez, J., Aussel, R., Girard, L., ... & Malissen, B. (2021). The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation. Journal of Experimental Medicine, 218(2).

Filgueira, L. M., Cervantes, J. B., Lovelle, O. A., Herrera, C., Figueredo, C., Caballero, J. A., ... & Caballero, A. (2021). An anti-CD6 antibody for the treatment of COVID-19 patients with cytokine-release syndrome: report of three cases. Immunotherapy, 13(4), 289-295.

Kureel, A. K., Saini, S., Singh, B., Singh, K., & Rai, A. K. (2021). Compromised levels of CD6 and reduced T cell activation in the aged immune system. Biomarkers, 1-8.

Dogra, S., & Rajagopalan, M. (2020). Anti-CD6 mAbs for the treatment of psoriasis. Expert Opinion on Biological Therapy, 20(10), 1215-1222.

Velasco-de Andrés, M., Casadó-Llombart, S., Català, C., Leyton-Pereira, A., Lozano, F., & Aranda, F. (2020). Soluble CD5 and CD6: Lymphocytic Class I Scavenger Receptors as Immunotherapeutic Agents. Cells, 9(12), 2589.

Gonçalves, C. M., Henriques, S. N., Santos, R. F., & Carmo, A. M. (2018). CD6, a rheostat-type signalosome that tunes T cell activation. Frontiers in immunology, 9, 2994.

Consuegra-Fernandez, M., Lin, F., Fox, D. A., & Lozano, F. (2018). Clinical and experimental evidence for targeting CD6 in immune-based disorders. Autoimmunity reviews, 17(5), 493-503.

Meddens, M., Mennens, S. F., Celikkol, F. B., Te Riet, J., Kanger, J. S., Joosten, B., ... & Cambi, A. (2018). Biophysical Characterization of CD6—TCR/CD3 Interplay in T Cells. Frontiers in immunology, 9, 2333.

Bughani, U., Saha, A., Kuriakose, A., Nair, R., Sadashivarao, R. B., Venkataraman, R., ... & Nair, P. (2017). T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab. PloS one, 12(7), e0180088.

Enyindah-Asonye, G., Li, Y., Ruth, J. H., Spassov, D. S., Hebron, K. E., Zijlstra, A., ... & Lin, F. (2017). CD318 is a ligand for CD6. Proceedings of the National Academy of Sciences, 114(33), E6912-E6921.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Rat Anti-CD6 Recombinant Antibody (CBFYC-1381)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare